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The Effects of Diet Induced Obesity on Central Nervous System Function of APOE Mice
(Georgetown University, 2021)
APOE4 is the strongest genetic risk factor for Alzheimer’s Disease (AD) and obesity is one of the most common environmental risk factors for AD. With 25% of the population being APOE4 carriers and 40% of the population ...
Multimodal Evidence for Neurocognitive Alterations in Pediatric Obesity
(Georgetown University, 2021)
Pediatric obesity is increasing in prevalence and severity in the United States, with one in five adolescents meeting criteria for overweight (body mass index; BMI for age and sex >85th percentile) and one in three meeting ...
Mapping the Neurocognitive Architecture of Reading
(Georgetown University, 2021)
Reading relies on at least partially dissociable sub-word (sublexical) and word-specific (lexical) processes, which are subserved by somewhat separable neural substrates. Beyond this broad dissociation between sublexical ...
A Translational Investigation of Discoidin Domain Receptor 1 Inhibition as a Novel Therapeutics Strategy in Neurodegenerative Disease
(Georgetown University, 2021)
Neurodegenerative diseases (ND) are gaining recognition as imminent health crises. The greatest unmet need in neurodegeneration is a disease modifying therapy, but the failures of drug development have not been for a lack ...
Organochlorines and Brain Homeostasis: Polychlorinated Biphenyls as Astrocytic Stressors
(Georgetown University, 2021)
Exposure to environmental toxicants is prevalent, hazardous and linked to varied detrimental health outcomes and disease. Polychlorinated biphenyls (PCBs), a class of hazardous organochlorines once widely used for industrial ...
The Learning and Persistence of Aesthetic Values
(Georgetown University, 2021)
Our aesthetic preferences are an integral part of our identity, they define us both as individuals and as members of our cultures. Yet very little is known about how they develop or persist over our lifetimes. Philosophical ...
The APOE4 Mouse as a Model of Chemotherapy-induced Cognitive Impairments and Senescence
(Georgetown University, 2021)
Cancer-related cognitive impairment (CRCI) occurs in 15-35% of breast cancer survivors and represents a major quality of life concern. CRCI has been linked to the APOE4 genotype, the strongest genetic risk factor for ...
Cerebellar Involvement in Reading and Math Disabilities
(Georgetown University, 2020)
Brain imaging studies have shown that the cerebellum, traditionally associated with motor function (Manto et al., 2012), is active during reading (Martin et al., 2015) and math (Arsalidou & Taylor, 2011). Cognitive deficits ...
Synaptic Kalirin-7 and Trio Interactomes Reveal a GEF Protein-dependent Neuroligin-1 Mechanism of Action
(Georgetown University, 2020)
The RhoGEFs Kalirin and Trio have emerged as significant regulators of synaptic plasticity, and their dysregulation has recently been associated across a range of neurodevelopmental and neurodegenerative disorders. Although ...
Sex-Linked Neuroligins and Their Roles at Synapses
(Georgetown University, 2020)
Autism spectrum disorder (ASD) is a neurodevelopmental disorder that results in social-communication impairments, restricted and repetitive behaviors, and is more prevalent in males. Although the underlying etiology of ASD ...