Search Full Text
Now showing items 1-6 of 6
α-SYNUCLEIN DISRUPTS INTEGRATED SIGNALING BY THE UNFOLDED PROTEIN RESPONSE THROUGH INHIBITION OF ATF6-α INCORPORATION INTO COPII VESICLES
(Georgetown University, 2015)
Parkinson's Disease (PD) is a neurodegenerative disease characterized by the advanced loss of motor functions as a result of progressive degenerative conditions that develop in many regions of the brain and manifest as a ...
Neuronal DNA Double Strand Break Damage and Repair Following Sublethal iGluR Activation, and the Neuroprotective Effects of Melatonin
(Georgetown University, 2013)
DNA double strand break (DSB) damage is among the most lethal forms of DNA damage, and its repair in mature neurons remains largely unexamined, particularly following neuronal excitation. A major cause of DSBs is mediated ...
Elucidating the Role of Plasticity-Related Gene Type 3 Protein in the Central Nervous System
(Georgetown University, 2018)
PRG-3 (Plasticity-Related Gene), a member of a family of lipid phosphatase related proteins, also known as Phospholipid Phosphatase-Related Protein Type (PLPPR) proteins, are integral membrane proteins characterized by six ...
Distinct Roles for EphA7 Isoforms in Cortical Dendritic Elaboration and Synapse Formation
(Georgetown University, 2017)
The cerebral cortex consists of complex circuitry that directs diverse functions. Development of the cortex relies upon precise coordination between inherent genetic programs and environmental signals to create distinct ...
Organochlorines and Brain Homeostasis: Polychlorinated Biphenyls as Astrocytic Stressors
(Georgetown University, 2021)
Exposure to environmental toxicants is prevalent, hazardous and linked to varied detrimental health outcomes and disease. Polychlorinated biphenyls (PCBs), a class of hazardous organochlorines once widely used for industrial ...
Hippocampal Microcircuit Alterations in Early Amyloid Pathology: A Selective Impairment of Parvalbumin-Expressing Basket Cells During Sharp Wave Ripple Events
(Georgetown University, 2020)
Memory disruption in mild cognitive impairment (MCI) and Alzheimer’s disease (AD) is poorly understood, particularly at early stages preceding neurodegeneration. In mouse models of AD, there are disruptions to sharp wave ...