The brain uses a special feature, synaptic plasticity, for learning and memory. As forms of synaptic plasticity, associative plasticity, long-term potentiation (LTP) and long-term depression (LTD), is a positive feedback ...

Substantial evidence has demonstrated that dendritic protein synthesis is an important source of new protein during the expression of synaptic plasticity. Dendritically synthesized brain-derived neurotrophic factor (BDNF) ...

Dendritic spines are the postsynaptic sites for the vast majority of excitatory synapses in the brain. They are highly dynamic structures that undergo changes in size, shape, and number during development, as well as in ...

DNA double strand break (DSB) damage is among the most lethal forms of DNA damage, and its repair in mature neurons remains largely unexamined, particularly following neuronal excitation. A major cause of DSBs is mediated ...

Neurogenesis is a tightly controlled developmental process through which neural progenitor cells progress to committed neurons. While the SoxB1 transcription factors are well characterized to have functions in the induction ...

Exposure to environmental toxicants is prevalent, hazardous and linked to varied detrimental health outcomes and disease. Polychlorinated biphenyls (PCBs), a class of hazardous organochlorines once widely used for industrial ...

Synucleinopathies are one of the most progressive age-related neurodegenerative family of disorders in the world, affecting millions of individuals worldwide. Debilitating cardinal motor symptoms in patients can present ...

Neurogenesis is a tightly controlled developmental process through which neural progenitor cells progress to committed neurons. While the SoxB1 transcription factors are well characterized to have functions in the induction ...