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Adolescent Neurocognitive Maturity Mediates Paths to Altered Social Norms and Vulnerability in Emerging Adulthood
(Georgetown University, 2020)
The transitional period between adolescence and adulthood is a high-risk period for social strain and adversity leading to experiences of violence and altered normative civic beliefs. In this dissertation, I examine cognitive ...
Behavioral Flexibility in Autism Spectrum Disorder: The Role of Memory and Its Neural Correlates
(Georgetown University, 2020)
Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder marked by social and behavioral deficits, including pronounced inflexibility. Behavioral interventions often fail to generalize, possibly due to difficulties ...
Investigation of Alpha-Synuclein Induced Disruption of Calcium Homeostasis in Synucleinopathies
(Georgetown University, 2020)
Synucleinopathies are one of the most progressive age-related neurodegenerative family of disorders in the world, affecting millions of individuals worldwide. Debilitating cardinal motor symptoms in patients can present ...
Assessing the Function of SOX21 in Xenopus laevis Neurogenesis: Exploring Homeolog Sub-Functionalization
(Georgetown University, 2021)
Neurogenesis is a tightly controlled developmental process through which neural progenitor cells progress to committed neurons. While the SoxB1 transcription factors are well characterized to have functions in the induction ...
Investigating The Neurocognitive Mechanisms of Error Monitoring in Aphasia
(Georgetown University, 2022)
Speech error monitoring (SEM) is critical for effective communication, and is especially important in aphasia, a language impairment commonly caused by stroke. The present dissertation employs three studies to investigate ...
Using Structural MRI to Examine the Neural Bases of Dyslexia, Dyscalculia, and ADHD in Children
(Georgetown University, 2021)
The neuroanatomical differences associated with the developmental disorder attention-deficit/hyperactivity disorder (ADHD) or the learning disabilities (LDs) dyslexia (or reading disability, RD) or dyscalculia (or math ...
It Sounds the Way It's Spelled: Orthography Effect Mechanisms in Persons with Aphasia
(Georgetown University, 2022)
The goal of this dissertation was to find converging evidence from behavioral and neuroimaging analyses of the mechanisms of orthographic integration with general language processes. By examining orthography effects, covert ...
Creatine Synthesis and Supplementation Regulates Central Nervous System Postnatal Development and Injury
(Georgetown University, 2021)
Cerebral creatine deficiency syndrome (CCDS) is an inborn error of metabolism characterized by intellectual delays, seizures, and autistic-like behavior. Exactly how endogenously synthesized creatine regulates central ...
Investigating the Architecture and Plasticity of the Auditory System through Spoken Word Recognition
(Georgetown University, 2021)
The auditory cortical system, like the visual cortical system, is thought to be organized into a dual-stream architecture consisting of an anterior ventral and a posterior dorsal stream. Under this framework, the anterior ...
From Perception to Social Connection: Assessing Deficits and Modulation of Empathic Processes to Study Human Social Behavior
(Georgetown University, 2021)
Perceiving and responding to the emotions of other individuals is thought to motivate adaptive social behaviors and help form strong interpersonal connections. Failure or manipulation of the empathic processes that subserve ...