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Interaction of Attention and Emotion Across Development and Disorder
(Georgetown University, 2012)
This dissertation examines how attention and emotion interact in early visual processing across typical development and in Attention Deficit/Hyperactivity Disorder (ADHD). To investigate early visual processing, we utilized ...
SPECIFICITY OF INHIBITORY CONTROL OF CORTICAL INTERNEURONS IN LAYER 4 OF MOUSE SOMATOSENSORY BARREL CORTEX
(Georgetown University, 2009)
Cortical processing of sensory information relies on a diversity of inhibitory control. This thesis examines the cell type specificity in layer 4 of mouse somatosensory barrel cortex of two understudied mechanisms of GABA ...
Novel Roles for TRPA1 and TRPV1 in nutrient sensing and obesity
(Georgetown University, 2011)
In the first part of this thesis I explored a role for the capsaicin receptor TRPV1 in the regulation of feeding and body mass. On a diet containing 4.5% fat, wild-type and TRPV1-null mice gained equivalent body mass. On ...
Sequelae of Neonatal Antiepileptic Drug Exposure in Rats
(Georgetown University, 2011)
Antiepileptic drugs (AEDs) are first-line seizure treatments. Despite use in pregnancy and early life, their impact on brain maturation is unclear. This can only be assessed in preclinical models (e.g., rats), as seizures ...
ROLE OF DENDRITIC BDNF SYNTHESIS IN ADULT NEUROGENESIS AND SPINE MORPHOGENESIS
(Georgetown University, 2011)
Substantial evidence has demonstrated that dendritic protein synthesis is an important source of new protein during the expression of synaptic plasticity. Dendritically synthesized brain-derived neurotrophic factor (BDNF) ...
FUNCTION AND SIGNAL TRANSDUCTION OF METABOTROPIC GLUTAMATE RECEPTOR 1 IN CEREBELLAR GRANULE CELLS
(Georgetown University, 2014)
Glutamate is the predominant excitatory neurotransmitter in the mammalian brain, activating ionotropic and metabotropic glutamate (mGlu1) receptors. mGlu1 receptors are highly expressed in cerebellar granule cells, but ...
DOPAMINE-REGULATING GENES, EXECUTIVE CONTROL, AND THE NETWORK STRUCTURE OF THE HUMAN BRAIN
(Georgetown University, 2013)
Executive control processes, including working memory (WM), attention, and impulse control, rely on brain networks centered in the prefrontal cortex, and especially on dopaminergic signaling in these networks. The function ...
Brain Oscillatory Dynamics of Lexical-Semantic Processing
(Georgetown University, 2013)
Neuropsychological and imaging studies have shown that anterior and posterior brain areas are involved in the retrieval and selection of semantic representations, but it is not known how these areas dynamically interact ...
Morphine activation of stress pathways alters peripheral immune cell signaling
(Georgetown University, 2008)
Morphine is routinely used as an analgesic for acute and chronic pain often in people at greater risk for infection, in spite of the fact that morphine suppresses immune function. Recent studies indicate that morphine ...
The Role of Midbrain-Derived Neurotrophin-3 in Adult Mice: A Novel Factor for Mood Regulation
(Georgetown University, 2016)
Neurotrophin-3 (NT-3), one of the neurotrophic factor, is substantially expressed in the midbrain dopaminergic neurons. Recent studies have shown that NT-3 promotes survival of immature medium-sized spiny neurons (MSNs) ...