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Defining the Factors that Regulate the Conversion to a Trailblazer Epithelial to Mesenchymal Transition State
(Georgetown University, 2021)
Tumor heterogeneity resulting from the co-existence of phenotypically diverse tumor cellpopulations is a major contributor in the pathogenesis of several human malignancies. In addition to the steady acquisition of heritable ...
Targeting WEE1 in Standard Therapy Resistant Estrogen Receptor Positive Breast Cancer
(Georgetown University, 2021)
Despite the success of antiestrogens in extending overall survival of patients with estrogen receptor positive (ER+) breast tumors, resistance to these therapies is prevalent. ER+ tumors that progress on antiestrogens are ...
Addressing Thoracic Cancers: Biomarker and Pre-Clinical Drug Discovery in Non-Small Cell Lung Cancer and Thymic Carcinoma
(Georgetown University, 2020)
Thoracic cancer is a term that encompasses numerous malignancies within the thoracic cavity; the term includes malignancies such as lung cancers and thymic epithelial tumors. Lung cancers are the leading cause of cancer ...
Prenatal Care in the United States: Perceptions of Resettled Bhutanese-Nepali Refugees
(Georgetown University, 2021)
The Bhutanese-Nepali community in the United States, estimated to be greater than 100,000, has been fleeing religious and ethnic persecution since the 1980s. Ohio ranks fifth in the United States in the number of resettled ...
Evaluation of a Staffing to Workload Tool in a Multispeciality Clinic Setting
(Georgetown University, 2021)
Increasing pressure to manage the cost of healthcare has resulted in shifting care towards ambulatory settings and is driving a focus on cost transparency. There are few nurse staffing to workload models developed for ...
Inside the Blue Box: Organizational Identity and Turf Decision-Making in the United States Air Force
(Georgetown University, 2021)
Why would a US military service relinquish a mission—a mission that could justify millions of dollars in new assets—while pursuing another to the point of near obsession? Why do these decisions regarding “turf,” that is, ...
Mapping the Neurocognitive Architecture of Reading
(Georgetown University, 2021)
Reading relies on at least partially dissociable sub-word (sublexical) and word-specific (lexical) processes, which are subserved by somewhat separable neural substrates. Beyond this broad dissociation between sublexical ...
Temples of Modern Pharaohs: An Environmental History of Dams and Dictatorship in Brazil, 1960s-1990s
(Georgetown University, 2021)
This dissertation is an environmental history of Brazil’s large dams, the country’s principal source of electricity. Hydropower undergirded economic growth, but reservoirs left huge social and environmental footprints. The ...
"In a Moment I Am Perfectly Myself": A Study of the Lesbian Vampire as Crip-Queer Subject
(Georgetown University, 2021)
This thesis is an exploration of the lesbian vampire as a character with the potential to be read as inhabiting a crip-queer subject position, one which troubles and challenges narratives of pathologization and demonization ...
Post-Imperial Waters: Oceanic Form and Politics in 21st-Century Global South Novels
(Georgetown University, 2021)
This thesis investigates the oceanic imaginaries of three contemporary Global South novels—Abdulrazak Gurnah’s By the Sea (2001), Zakes Mda’s The Whale Caller (2005), and Yvonne Adhiambo Owuor’s The Dragonfly Sea (2019). ...