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Pou3f4-Expressing Otic Mesenchyme Cells: A Novel Influence for Cochlear Spiral Ganglion Neuron Survival
(Georgetown University, 2022)
Current therapies to improve hearing, including hearing aids and cochlear implants, require intact and functional auditory neurons. Within the inner ear, the primary auditory neurons, called spiral ganglion neurons (SGNs), ...
Investigating the Impact of Pancreatic Cancer Derived Extracellular Vesicles on the Tumor Microenvironment
(Georgetown University, 2022)
Pancreatic ductal adenocarcinoma (PDAC) is a deadly disease with a 5-year survival rate of ~11%. Late-stage diagnosis of disease is a key driver of poor outcomes. To improve patient survival, a better understanding of early ...
A Comprehensive Metagenomic Study of the Antarctic Untersee Oasis as an Astrobiological Analog
(Georgetown University, 2022)
Astrobiology is the study of the “living universe,” which includes the study of the origin of lifeas well as its evolution and distribution on Earth and beyond. Prime candidates for alien life
include the icy moons of the ...
HIV TAT Induced Gliosis and Changes in Perineuronal Nets and Parvalbumin Positive Interneurons
(Georgetown University, 2022)
HIV (human immunodeficiency virus) is a retrovirus affecting approximately 1.2 million people in the United States according to the CDC. This virus causes severe damage to the immune system eventually leading to acquired ...
Regularized Local Smoothing for Longitudinal Analysis with Time-Varying Coefficient Models and Transformation Models
(Georgetown University, 2022)
This dissertation concerns selecting locally influential variables in both conditional mean and conditional distribution-based models with high-dimensional longitudinal data. Motivated by a large epidemiological study for ...
Traces of Extremity in the Aftermath, a Collection: Haruki Murakami, W.G. Sebald, and Carolyn Forché
(Georgetown University, 2021)
This thesis reexamines the careers and works of three contemporary writers: the Japanese novelist Haruki Murakami, the German writer and academic W.G. Sebald, and the American poet, memoirist, and human rights activist ...
Urban Fail
(Georgetown University, 2022)
American urban core cities have been in a crisis that commenced in the middle of the last century and has not abated. The outmigration of economically diverse populations and capital threatens the economic sustainability ...
SMALL TEXTS, BIG PRESUMPTIONS: The intersection of material science and social science in the authentication of suspect Dead Sea Scrolls fragments
(Georgetown University, 2021)
Abstract:Since 2002, many previously unknown textual fragments inscribed in Hebrew or Aramaic have surfaced on the antiquities market. Believed to be newly discovered biblical artifacts belonging to the canon of the Dead ...
JUST TRANSITION: ELECTRIC DISTRIBUTION UTILITIES HEADING INTO A DECARBONIZING WORLD
(Georgetown University, 2022)
Electric distribution utilities link individuals to the vast infrastructure involved in generating electricity. Because of the utilities’ intermediary role, it is important to study whether justice or injustice is considered ...
Las políticas de desarme civil desde el estado. Análisis de las capacidades estatales del Programa Nacional de Entrega Voluntaria de Armas de Fuego en la República Argentina (2007-2015)
(Georgetown University, 2022)
El objetivo de este estudio es analizar las capacidades estatales necesarias para la implementación del Programa Nacional de Entrega Voluntaria de Armas de Fuego en la República Argentina (2007-2015) como política de desarme ...