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Somatostatin-GABA neurons regulate vago-vagal circuitry
(Georgetown University, 2016)
Parasympathetic regulation of the gastric antrum is mediated through the vago-vagal circuitry in which glutamatergic afferents relay peripheral information to the CNS and cholinergic efferents transmit the compensatory ...
The Effects of Inflammation on Dorsal Striatal Spiny Projection Neurons
(Georgetown University, 2017)
Neuroinflammation precedes neuronal loss in striatal neurodegenerative diseases and can be exacerbated by the release of proinflammatory molecules by microglia. These molecules can affect trafficking of glutamate receptors. ...
Novel Roles for TRPA1 and TRPV1 in nutrient sensing and obesity
(Georgetown University, 2011)
In the first part of this thesis I explored a role for the capsaicin receptor TRPV1 in the regulation of feeding and body mass. On a diet containing 4.5% fat, wild-type and TRPV1-null mice gained equivalent body mass. On ...
Sequelae of Neonatal Antiepileptic Drug Exposure in Rats
(Georgetown University, 2011)
Antiepileptic drugs (AEDs) are first-line seizure treatments. Despite use in pregnancy and early life, their impact on brain maturation is unclear. This can only be assessed in preclinical models (e.g., rats), as seizures ...
FUNCTION AND SIGNAL TRANSDUCTION OF METABOTROPIC GLUTAMATE RECEPTOR 1 IN CEREBELLAR GRANULE CELLS
(Georgetown University, 2014)
Glutamate is the predominant excitatory neurotransmitter in the mammalian brain, activating ionotropic and metabotropic glutamate (mGlu1) receptors. mGlu1 receptors are highly expressed in cerebellar granule cells, but ...
The Role of Midbrain-Derived Neurotrophin-3 in Adult Mice: A Novel Factor for Mood Regulation
(Georgetown University, 2016)
Neurotrophin-3 (NT-3), one of the neurotrophic factor, is substantially expressed in the midbrain dopaminergic neurons. Recent studies have shown that NT-3 promotes survival of immature medium-sized spiny neurons (MSNs) ...
THE ROLE OF METABOTROPIC GLUTAMATE RECEPTOR 1 IN HUMAN MELANOMA
(Georgetown University, 2015)
Metabotropic glutamate 1 (mGlu1) receptor has been proposed as a target for the treatment of metastatic melanoma. In this thesis, we investigated the role of mGlu1 receptors in melanoma cell growth and death, and aim to ...
Chronic morphine vs. morphine withdrawal: differential effects on HIV neurotoxicity through the expression of CCL5
(Georgetown University, 2014)
The effect of opioids in the progression of Human Immunodeficiency Virus (HIV)-associated Neurocognitive Disorders (HAND) remains under debate. M-tropic, CCR5-receptor preferring strains of HIV are associated with primary ...
Dopamine D2 Receptor Activation on Striatal Inhibitory Collaterals
(Georgetown University, 2013)
The principal neurons of the striatum are GABAergic medium spiny neurons (MSNs), whose collateral synapses onto neighboring neurons play critical roles in striatal function. MSNs can be divided by dopamine receptor expression ...
Experimental Studies of Subdiaphragmatic Vagotomy and Nicotine for Reducing Body Weight
(Georgetown University, 2014)
Melanocortin neural circuits are important regulators of food intake (FI) and body weight (BW). The hypothesis of the first part of my dissertation is that the dorsal motor nucleus of the vagus (DMV) represents an important ...