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Cover for Changes in Hippocampal Synaptic Plasticity Following Exposure to High Frequency Head Impacts (HF-HI)

Changes in Hippocampal Synaptic Plasticity Following Exposure to High Frequency Head Impacts (HF-HI)

Sloley, Stephanie Simone (Georgetown University, 2020)

Concussions account for over 80% of all cases of TBI reported each year. Sustaining multiple concussions is associated with the development of lasting cognitive and memory impairments. Chronic traumatic encephalopathy ...

Cover for Hippocampal Microcircuit Alterations in Early Amyloid Pathology: A Selective Impairment of Parvalbumin-Expressing Basket Cells During Sharp Wave Ripple Events

Hippocampal Microcircuit Alterations in Early Amyloid Pathology: A Selective Impairment of Parvalbumin-Expressing Basket Cells During Sharp Wave Ripple Events

Caccavano, Adam Peter (Georgetown University, 2020)

Memory disruption in mild cognitive impairment (MCI) and Alzheimer’s disease (AD) is poorly understood, particularly at early stages preceding neurodegeneration. In mouse models of AD, there are disruptions to sharp wave ...