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Somatostatin-GABA neurons regulate vago-vagal circuitry
(Georgetown University, 2016)
Parasympathetic regulation of the gastric antrum is mediated through the vago-vagal circuitry in which glutamatergic afferents relay peripheral information to the CNS and cholinergic efferents transmit the compensatory ...
The Effects of Inflammation on Dorsal Striatal Spiny Projection Neurons
(Georgetown University, 2017)
Neuroinflammation precedes neuronal loss in striatal neurodegenerative diseases and can be exacerbated by the release of proinflammatory molecules by microglia. These molecules can affect trafficking of glutamate receptors. ...
Novel Roles for TRPA1 and TRPV1 in nutrient sensing and obesity
(Georgetown University, 2011)
In the first part of this thesis I explored a role for the capsaicin receptor TRPV1 in the regulation of feeding and body mass. On a diet containing 4.5% fat, wild-type and TRPV1-null mice gained equivalent body mass. On ...
Cholinergic Modulation of GABAergic Inhibition Dynamics In The Striatum
(Georgetown University, 2014)
The striatum contains medium spiny neurons (MSNs) classified by their axonal projection and expression of dopamine receptors into D1+ and D2+ MSNs; and interneurons including choline acetyltransferase expressing interneurons ...
Changes in Hippocampal Synaptic Plasticity Following Exposure to High Frequency Head Impacts (HF-HI)
(Georgetown University, 2020)
Concussions account for over 80% of all cases of TBI reported each year. Sustaining multiple concussions is associated with the development of lasting cognitive and memory impairments. Chronic traumatic encephalopathy ...