Derivation of Oocytes From Mouse Embryonic Stem Cells
Christenson, Lane K.
De La Fuente, Rabindranath
Strauss, Jerome F., III
Scholer, Hans R.
Science 2003 May 23; 300(5623): 1251-1256
Continuation of mammalian species requires the formation and development of the sexually dimorphic germ cells. Cultured embryonic stem cells are generally considered pluripotent rather than totipotent because of the failure to detect germline cells under differentiating conditions. Here we show that mouse embryonic stem cells in culture can develop into oogonia that enter meiosis, recruit adjacent cells to form follicle-like structures, and later develop into blastocysts. Oogenesis in culture should contribute to various areas, including nuclear transfer and manipulation of the germ line, and advance studies on fertility treatment and germ and somatic cell interaction and differentiation.
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The German Research Society (DFG) Research Project: New Perspectives in Transplantation Medicine: The Biological, Medical and Ethical Aspects of Xenotransplantation and the Derivation of Organs from Embryonic Stem Cells Engels, Eve-Marie; Lotter, Gisela; Schicktanz, Silke (1999)