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dc.creatorPaulson, Richard J.en
dc.creatorBoostanfar, Roberten
dc.creatorSaadat, Peymanen
dc.creatorMor, Eliranen
dc.creatorTourgeman, David E.en
dc.creatorSlater, Cristin C.en
dc.creatorFrancis, Mary M.en
dc.creatorJain, John K.en
dc.date.accessioned2016-01-09T00:15:18Zen
dc.date.available2016-01-09T00:15:18Zen
dc.date.created2002-11-13en
dc.date.issued2002-11-13en
dc.identifierdoi:10.1001/jama.288.18.2320en
dc.identifier.bibliographicCitationJAMA: The Journal of the American Medical Association 2002 November 13; 288(18): 2320-2323en
dc.identifier.urihttp://worldcatlibraries.org/registry/gateway?version=1.0&url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&atitle=Pregnancy+in+the+sixth+decade+of+life&title=JAMA:+The+Journal+of+the+American+Medical+Association+&volume=288&issue=18&spage=2320-2323&date=2002-11&au=Paulson,+Richard+J.;+Boostanfar,+Robert;+Saadat,+Peyman;+Mor,+Eliran;+Tourgeman,+David+E.;+Slater,+Cristin+C.;+Francis,+Mary+M.;+Jain,+John+K.en
dc.identifier.urihttp://dx.doi.org/10.1001/jama.288.18.2320en
dc.identifier.urihttp://hdl.handle.net/10822/1006395en
dc.description.abstractCONTEXT: As a result of oocyte donation, women in their sixth decade of life are now able to conceive and carry pregnancies to term. However, little is known about pregnancy outcomes in this population. OBJECTIVE: To describe pregnancy outcomes in women aged 50 years or older who conceived after in vitro fertilization with donor oocytes. DESIGN AND SETTING: Retrospective analysis of cycles conducted at a US university assisted reproduction program during calendar years 1991-2001. PATIENTS: Seventy-seven postmenopausal women with no chronic medical conditions (mean [SD] age, 52.8 [2.9] years; range, 50-63 years) who underwent 121 embryo transfer procedures (89 fresh and 32 frozen). Pregnancy outcomes were ascertained by chart review and telephone follow-up. MAIN OUTCOME MEASURES: Maternal and neonatal outcomes. RESULTS: There were 55 clinical pregnancies for a total pregnancy rate of 45.5%. The live birth rate was 37.2%. Of the 45 live births, 31 were singletons, 12 were twins, and 2 were triplets, for which the mean (SD) gestational ages at delivery were 38.4 (2.1) weeks, 35.8 (2.8) weeks, and 32.2 weeks, respectively. Mean (SD) birth weights were 3039 g (703 g), 2254 g (581 g), and 1913 g, respectively. Apgar scores at 1 and 5 minutes were 8.2 (0.9) and 9.1 (0.5), respectively. Of singletons, 68% were delivered by cesarean, and all multiples were delivered by cesarean. Mild preeclampsia was noted in 25% of patients and severe preeclampsia in 10%. Gestational diabetes required diet modification in 17.5%, and 2.5% required insulin. CONCLUSIONS: Appropriately screened women aged 50 years or older can successfully conceive via oocyte donation and experience similar pregnancy rates, multiple gestation rates, and spontaneous abortion rates as younger recipients. During pregnancy, they appear at increased risk of preeclampsia and gestational diabetes. A majority can expect to deliver via cesarean. However, there does not appear to be any definitive medical reason for excluding these women from attempting pregnancy on the basis of age alone.en
dc.formatArticleen
dc.languageenen
dc.sourceeweb:251782en
dc.subjectAbortionen
dc.subjectAgeden
dc.subjectDiabetesen
dc.subjectEmbryo Transferen
dc.subjectIn Vitro Fertilizationen
dc.subjectInsulinen
dc.subjectLifeen
dc.subjectPatientsen
dc.subjectPregnancyen
dc.subjectReproductionen
dc.subjectReviewen
dc.subjectRisken
dc.subjectTwinsen
dc.subject.classificationIn Vitro Fertilization and Embryo Transferen
dc.subject.classificationHealth Care Programs for Womenen
dc.titlePregnancy in the Sixth Decade of Lifeen
dc.provenanceCitation prepared by the Library and Information Services group of the Kennedy Institute of Ethics, Georgetown University for the ETHXWeb database.en
dc.provenanceCitation migrated from OpenText LiveLink Discovery Server database named EWEB hosted by the Bioethics Research Library to the DSpace collection EthxWeb hosted by DigitalGeorgetown.en


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