Psychometric Testing of the Decisional Conflict Scale: Genetic Testing Hereditary Breast and Ovarian Cancer
Katapodi, Maria C
Munro, Michelle L
Pierce, Penny F
Williams, Reg A
Nursing research 2011 Nov-Dec; 60(6): 368-77
: Hereditary breast and ovarian cancer (HBOC) syndrome is attributed mostly to mutations in the Breast Cancer 1 and Breast Cancer 2 genes (BRCA1/2). Mutation carriers of BRCA1/2 genes have significantly higher risk for developing breast cancer compared with the general population (55%-85% vs. 12%) and for developing ovarian cancer (20%-60% vs. 1.5%). The availability of genetic testing enables mutation carriers to make informed decisions about managing their cancer risk (e.g., risk-reducing surgery). However, uptake of testing for HBOC among high-risk individuals is low, indicating the need to better understand and measure the decisional conflict associated with this process.
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