Relative Versus Absolute Standards for Everyday Risk in Adolescent HIV Prevention Trials: Expanding the Debate
Miller, Cari L
The American journal of bioethics : AJOB 2011 Jun; 11(6): 5-13
The concept of minimal risk has been used to regulate and limit participation by adolescents in clinical trials. It can be understood as setting an absolute standard of what risks are considered minimal or it can be interpreted as relative to the actual risks faced by members of the host community for the trial. While commentators have almost universally opposed a relative interpretation of the environmental risks faced by potential adolescent trial participants, we argue that the ethical concerns against the relative standard may not be as convincing as these commentators believe. Our aim is to present the case for a relative standard of environmental risk in order to open a debate on this subject. We conclude by discussing how a relative standard of environmental risk could be defended in the specific case of an HIV vaccine trial among adolescents in South Africa.
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Response to Open Peer Commentaries on "Relative Versus Absolute Standards for Everyday Risk in Adolescent HIV Prevention Trials: Expanding the Debate" Snyder, Jeremy; Miller, Cari L; Gray, Glenda (2011-06)
HIV Prevention Responsibilities in HIV Vaccine Trials: Complexities Facing South African Researchers Essack, Zaynab; Slack, Catherine; Koen, Jennifer; Gray, Glenda (2010-01)Researchers should protect the welfare of research participants through providing methods to reduce their risk of acquiring HIV. This is especially important given that late-phase HIV vaccine trials enrol HIV-uninfected ...