Novel Approaches to Expanding the Lung Donor Pool: Donation After Cardiac Death and Ex Vivo Conditioning
Yeung, Jonathan C
Clinics in chest medicine 2011 Jun; 32(2): 233-44
Two novel approaches have been developed to potentially increase the availability of donor lungs for lung transplantation. In the first approach, lungs from donation after cardiac death (DCD) donors are used to increase the quantity of organ donors. In the second approach, a newly developed normothermic ex vivo lung perfusion (EVLP) technique is used as a means of reassessing the adequacy of lung function from DCD and from high-risk brain death donors prior to transplantation. This EVLP technique can also act as a platform for the delivery of novel therapies to repair injured organs ex vivo.
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Successful Lung Transplant From Donor After Cardiac Death: A Potential Solution to Shortage of Thoracic Organs McKellar, Stephen H.; Durham, Lucian A., 3rd.; Scott, John P.; Cassivi, Stephen D. (2010-02)Lung transplant is an effective treatment for patients with end-stage lung disease but is limited because of the shortage of acceptable donor organs. Organ donation after cardiac death is one possible solution to the organ ...