From Bench to Bedside and to Health Policies: Ethics in Translational Research
La Clinica terapeutica 2011 Jan-Feb; 162(1): 51-9
Translation of biomedical research knowledge to effective clinical treatment is essential to the public good. The first level of translation ("from bench to bedside") corresponds to efficacy studies under controlled conditions with careful attention to internal validity (clinical research). The second level is the translation of results from clinical studies into everyday clinical practice and health decision making. The article summarises the ethical issues involved in the translation of biomedical research advances to clinical applications and to clinical practice. In particular, the article synthesizes theory from clinical ethics, operational design, and philosophy to examine the unique bioethical issues raised by the recent focus on translational research. In this framework safety of study participants and balancing of risk due to treatment with the potential benefits of the research are crucial: in clinical research there is a danger that the emphasis on advancements in scientific knowledge might prevail over the protection of the people who participate in research. These issues involve basic scientists, clinicians and bioethicists because of their application to comparative effectiveness research, clinical trials and evidence-based medicine, as well basic biomedical research.
Bioethical Issues; Biomedical Research; Clinical Ethics; Clinical Trials; Comparative Effectiveness Research; Clinical Research; Decision Making; Ethics; Evidence-Based Medicine; Health; Knowledge; Medicine; Philosophy; Research; Risk; Translational Research; Science, Technology, and Society; Human Experimentation Policy Guidelines / Institutional Review Boards;
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