Unrealistic Optimism in Early-Phase Oncology Trials
Jansen, Lynn A
Appelbaum, Paul S
Klein, William M P
Weinstein, Neil D
Fogel, Jessica S
Sulmasy, Daniel P
IRB 2011 Jan-Feb; 33(1): 1-8
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Expectations of Benefit in Early-Phase Clinical Trials: Implications for Assessing the Adequacy of Informed Consent Weinfurt, Kevin P.; Seils, Damon M.; Tzeng, Janice P.; Compton, Kate L.; Sulmasy, Daniel P.; Astrow, Alan B.; Solarino, Nicholas A.; Schulman, Kevin A.; Meropol, Neal J. (2008-07)
The Culture of Faith and Hope: Patients' Justifications for Their High Estimations of Expected Therapeutic Benefit When Enrolling in Early Phase Oncology Trials Sulmasy, Daniel P; Astrow, Alan B; He, M Kai; Seils, Damon M; Meropol, Neal J; Micco, Ellyn; Weinfurt, Kevin P (2010-08-01)BACKGROUND: Patients' estimates of their chances of therapeutic benefit from participation in early phase trials greatly exceed historical data. Ethicists worry that this therapeutic misestimation undermines the validity ...