Design Issues in Cancer Screening Trials
Statistical methods in medical research 2010 Oct; 19(5): 451-61
Randomised controlled trials avoid many of the potential biases associated with the evaluation of cancer screening. Nevertheless there are many issues concerning the design of such trials that require careful consideration and that will influence interpretation of the results. This article discusses issues related to recruitment and randomisation, which will affect the extent to which the population studied, is representative of the eventual target population of a screening programme. It addresses sample size considerations, the use of appropriate outcome measures and the timing of the intervention. Finally, issues related to ensuring appropriate analyses are discussed.
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Le Depistage Du Cancer Du Sein: Problemes Ethiques -- L'Experience De Strasbourg. Les Problemes Deontologiques Poses Par Le Depistage Du Cancer Du Sein: L'Assurance Qualite Et l'Accreditation Des Structures. Breast Cancer Screening: Ethical Issues -- the Strasbourg Experiment. Ethical Issues Raised by Breast Cancer Screening: Quality Management and Medical Structures Accreditation Haehnel, Pierre (1998)