Enhancing HIV Vaccine Trial Consent Preparedness Among Street Drug Users
Fisher, Celia B
Journal of empirical research on human research ethics : JERHRE 2010 Jun ; 5(2): 65-80
This research used open-ended and true-false questions to assess the preparedness of 96 ethnically diverse, economically and socially marginalized adult street drug users to consent to participate in HIV vaccine trials (HVT). Specific areas of consent vulnerability included misconceptions about: (1) the recuperative value and risk of vaccines in general; (2) the presence of the HIV virus within the vaccine and the possibility of contracting or transmitting HIV as a consequence of participation; (3) inclusion criteria and experimental blinds; and (4) distrust in the medical and research establishments. A brief HVT lesson administered to 30 participants was effective in correcting specific HVT knowledge misperceptions and increasing certain, but not all areas of HVT trust. Assessment of post-lesson responses to ethics-relevant questions provides information on respondents' attitudes toward AIDS safe behavior, research risks and benefits, monetary compensation, and willingness to participate. Implications for enhancing informed consent for HVT involving active drug users are discussed.
Aids; Attitudes; Compensation; Consent; Ethics; Informed Consent; Knowledge; Research; Risk; Risks and Benefits; Trust; Vaccines; Drugs and Drug Industry; Informed Consent or Human Experimentation; Acquired Immunodeficiency Syndrome or HIV Infection; Health Care for Substance Abusers / Users of Controlled Substances;
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Medical Eligibility, Comprehension of the Consent Process, and Retention of Injection Drug Users Recruited for an HIV Vaccine Trial Harrison, Katherine; Vlahov, David; Jones, Kathleen; Charron, Karen; Clements, Mary Lou (1995-11-01)Injection drug users (IDUs) at high risk for human immunodeficiency virus (HIV) infection are being identified as a population for HIV vaccine trials. We studied willingness of drug users to enroll and their comprehension ...
Medical Eligibility, Comprehension of the Consent Process, and Retention of Injection Drug Users Recruited for an HIV Vaccine Trial Harrison, Katherine; Vlahov, David; Jones, Kathleen; Charron, Karen; Clements, Mary Lou (1995-11-01)
Fisher, Celia B (2011)This study used semi-structured interviews and content analysis to examine moral principles that street drug users apply to three hypothetical addiction research ethical dilemmas. Participants (n = 90) were ethnically ...