Altruistic Donor-Triggered Domino-Paired Kidney Donation for Unsuccessful Couples From the Kidney-Exchange Program
Roodnat, J I
van de Wetering, J
de Klerk, M
Erdman, R A M
Massey, E K
Hilhorst, M T
Ijzermans, J N M
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2010 Apr; 10(4): 821-7
Between January 2000 and July 2009, 132 individuals inquired about altruistic kidney donation to strangers. These donors were willing to donate to genetically and emotionally unrelated patients. Some altruistic donors wished to donate to a specific person, but most wished to donate anonymously. In domino-paired donation, the altruistic donor donates to the recipient of an incompatible couple; the donor of that couple (domino-donor) donates to another couple or to the waiting list. In contrast to kidney-exchange donation where bilateral matching of couples is required, recipient and donor matching are unlinked in domino-paired donation. This facilitates matching for unsuccessful couples from the kidney-exchange program where blood type O prevails in recipients and is under-represented in donors. Fifty-one altruistic donors (39%) donated their kidney and 35 domino-donors were involved. There were 29 domino procedures, 24 with 1 altruistic donor and 1 domino-donor, 5 with more domino-donors. Eighty-six transplantations were performed. Donor and recipient blood type distribution in the couples limited allocation to blood type non-O waiting list patients. The success rate of domino-paired donation is dependent on the composition of the pool of incompatible pairs, but it offers opportunities for difficult to match pairs that were unsuccessful in the kidney-exchange program.
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Altruistic Donor Triggered Domino-Paired Kidney Donation for Unsuccessful Couples From the Kidney-Exchange Program Roodnat, J I; Zuidema, W; van de Wetering, J; de Klerk, M; Erdman, R A M; Massey, E K; Hilhorst, M T; Ijzermans, J N M; Weimar, W (2010-04)Between January 2000 and July 2009, 132 individuals inquired about altruistic kidney donation to strangers. These donors were willing to donate to genetically and emotionally unrelated patients. Some altruistic donors ...
de Klerk, Marry; Zuidema, Willij C; Ijzermans, Jan N M; Weimar, Willem (2009)Kidney transplantations with living related and unrelated donors are the optimal option for patients with end-stage renal disease. For patients with a willing--but blood-type or HLA incompatible donor--a living-donor kidney ...
Massey, E K; Kranenburg, L W; Zuidema, W C; Hak, G; Erdman, R A M; Hilhorst, M; Ijzermans, J N M; Busschbach, J J; Weimar, W (2010-06)In a growing number of transplant centers worldwide, altruistic donors are accepted to anonymously donate a kidney to a stranger. An important hesitation to expand these transplantation programs is the fear of evoking ...