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dc.creatorHowick, Jeremyen
dc.date.accessioned2016-01-09T00:46:07Zen
dc.date.available2016-01-09T00:46:07Zen
dc.date.created2009-09en
dc.date.issued2009-09en
dc.identifierdoi:10.1080/15265160903090041en
dc.identifier.bibliographicCitationAmerican Journal of Bioethics 2009 September; 9(9): 34-48en
dc.identifier.urihttp://worldcatlibraries.org/registry/gateway?version=1.0&url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&atitle=Questioning+the+methodologic+superiority+of+'placebo'+over+'active'+controlled+trials.&title=American+Journal+of+Bioethics+&volume=9&issue=9&date=2009-09&au=Howick,+Jeremyen
dc.identifier.urihttp://dx.doi.org/10.1080/15265160903090041en
dc.identifier.urihttp://hdl.handle.net/10822/1027062en
dc.description.abstractA resilient issue in research ethics is whether and when a placebo-controlled trial (PCT) is justified if it deprives research subjects of a recognized treatment. The clinicians' moral duty to provide the best available care seems to require the use of 'active' controlled trials (ACTs) that use an established treatment as a control whenever such a therapy is available. In another regard, ACTs are supposedly methodologically inferior to PCTs. Hence, the moral duty of the clinical researcher to use the best methods will favor PCTs. In this target article, I analyze the three reasons for believing that ACTs are inferior to PCTs namely: 1) ACTs lack 'assay sensitivity'; 2) ACTs do not measure absolute effect size; and 3) ACTs require more participants; and I contend that none are acceptable. Consequently the tension between clinical and research ethics dissolves: the moral duty of the clinician to avoid PCTs is unopposed by methodological considerations.en
dc.formatArticleen
dc.languageenen
dc.sourceeweb:327021en
dc.subjectEthicsen
dc.subjectMethodsen
dc.subjectResearchen
dc.subjectResearch Ethicsen
dc.subjectResearch Subjectsen
dc.subject.classificationHuman Experimentation Policy Guidelines / Institutional Review Boardsen
dc.subject.classificationInformed Consent or Human Experimentationen
dc.titleQuestioning the Methodologic Superiority of 'Placebo' Over 'Active' Controlled Trialsen
dc.provenanceCitation prepared by the Library and Information Services group of the Kennedy Institute of Ethics, Georgetown University for the ETHXWeb database.en
dc.provenanceCitation migrated from OpenText LiveLink Discovery Server database named EWEB hosted by the Bioethics Research Library to the DSpace collection EthxWeb hosted by DigitalGeorgetown.en


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