Multimodal Magnetic Resonance Image Fusion and Fluorescent Microthermal Imaging of Magnetic Hyperthermia
Van Keuren, Edward
T1 and T2 contrast agents have been widely used to enhance magnetic resonance imaging (MRI) performance. Dual-mode contrast agent (DMCA) integrated with properties from both T1 and T2 contrast agents combine imaging modalities and have advantages over single-mode contrast agents. Applying algorithms to the image processing can greatly enhance DMCA MRI.Various computational approaches to obtain MRI with better quality were investigated through DMCA MR image fusion. Five algorithms: AND Gate (AND), Contrast Division (CD), Nearest Neighbor Method (NNM), Gradient Highlight (GH), and Controlled Gradient Highlight (CGH), were developed and studied. By using dual-mode MRI contrast agent and image fusion algorithms, the sensitivity and spatial resolution of MRI can be enhanced significantly.In addition, magnetic particle hyperthermia (MPH) is a promising cancer treatment that is based on local hyperthermia of tumors. MPH uses magnetic particles to absorb energy from an alternating magnetic field and convert it into heat. Fluorescent microthermal imaging (FMI) is a technique to measure temperature variations on microscopic length scales by imaging a dye with a strong temperature-dependent fluorescence emission. FMI for MPH was developed and performed on thenoyltrifluoroacetonate (EuTTA)/iron oxide/polymethyl methacrylate(PMMA) films. FMI temperature maps were obtained and showed that the temperature of the sample film continued to increase after being exposed to an alternating magnetic field, and the heating effect decreased with increasing distance to the heating source. This study showed that the temperature distribution of MPH can be obtained by FMI, which has significant advantages over traditional calorimetric measurements.
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