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    Multimodal Evidence for Neurocognitive Alterations in Pediatric Obesity

    Cover for Multimodal Evidence for Neurocognitive Alterations in Pediatric Obesity
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    View/Open: Rajan_georgetown_0076D_14956.pdf (11.MB) Bookview

    Creator
    Rajan, Laya
    Advisor
    Vaidya, Chandan J
    ORCID
    0000-0002-3999-743X
    Abstract
    Pediatric obesity is increasing in prevalence and severity in the United States, with one in five adolescents meeting criteria for overweight (body mass index; BMI for age and sex >85th percentile) and one in three meeting criteria for obesity (BMI for age and sex >95th percentile). Eight percent of adolescents have severe obesity (BMI for age and sex > 120% above the 95th percentile). Obesity is associated with a host of consequences for every organ system, including cardiovascular disease, endocrine disruption, and marked differences in neurocognition. Cognitive deficits in domains such as reward processing may be both cause and consequence of obesogenic behaviors. The underlying structural and functional brain differences, however, are not well understood in adolescents. This understanding is important since adolescents are in a developmental period vulnerable to risk-taking and negative outcomes for health, cognition, and adaptive functioning. The three studies in this dissertation sought to 1) characterize how severe obesity and bariatric surgery affect structural properties of the brain, 2) explore obesity’s effects on reward in the brain across a range of BMIs and at the level of severe obesity, and probe the brain-eating behavior relationship, and 3) relate alterations in neural connectivity and activation to behavioral measures of reward-related decision-making.
    Description
    Ph.D.
    Permanent Link
    http://hdl.handle.net/10822/1062371
    Date Published
    2021
    Subject
    adolescent; development; fMRI; neuroimaging; obesity; plasticity; Neurosciences; Medicine; Neurosciences; Medicine;
    Type
    thesis
    Publisher
    Georgetown University
    Extent
    115 leaves
    Collections
    • Graduate Theses and Dissertations - Neuroscience
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    • Cover for Neurocognitive Deficits In Pediatric Obesity

      Neurocognitive Deficits In Pediatric Obesity 

      Pearce, Alaina Lundberg (Georgetown University, 2017)
      In the United States, 20% of adolescents suffer from obesity (body mass index—BMI—above the 95th percentile) and 8% of adolescents suffer from severe obesity (BMI 120% above the 95th percentile). Obesity carries increased ...
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    Georgetown University Seal
    ©2009 - 2022 Georgetown University Library
    37th & O Streets NW
    Washington DC 20057-1174
    202.687.7385
    digitalscholarship@georgetown.edu
    Accessibility