This subseries consists of letters sent by the Jesuit Superior General in Rome to the Maryland Province, and spans the years 1759 to 1935. The Superior General, the leader of the Society of Jesus elected by its General Congregation, wrote regularly to the Maryland Province to clarify the rules and regulations of the Society, interpret Papal decrees, authorize the establishment of new missions, mediate relations among Provinces, and announce the appointments of Rectors, Superiors, and Procurators. Most of the letters in this subseries are written in Latin and concern issues such as the performance of Masses, the celebration of holy days, and the rules of conduct for members. Letters written directly to Maryland Provincials also contain incisive observations on local conditions and address issues including missionary activity among African Americans, the immigration of priests, the curriculum of Jesuit novitiates and schools, and the jurisdiction of the Maryland Province (including the consolidation of the Maryland and New York Provinces in 1879, and the formation of a separate New England Vice-Province in 1921). Of special note are letters from Superior General Jan Roothan to Maryland Provincial Thomas Mulledy (December 27, 1836, and September 12, 1838) that authorized and defined the conditions of the mass sale of 272 enslaved individuals in 1838 by the Province.

The Province sent the materials that comprise this subseries to Georgetown University with its initial deposit in 1977. The subseries is arranged first by the type of recipient, and then chronologically. In addition to original letters written by the Superior General, the subseries contains five copy books, created by the Maryland Province, of letters received by the Superior General (covering the period from May 12, 1804 to November 5, 1873). The subseries also consists of circular letters that were written for and sent to Provincials globally (collectively called the Congregation of Provincials, and spanning the period November 7, 1825-June 19, 1906); and letters written to the General Congregation, a representative body selected by fully-professed members that met regularly in Rome to discuss constitutional matters and global issues (January 1, 1848-March 25, 1935).