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dc.creatorWeissman, Irving L.en
dc.date.accessioned2011-07-12T18:19:01Zen
dc.date.available2011-07-12T18:19:01Zen
dc.date.created2005-09-21en
dc.date.issued2005-09-21en
dc.identifierhttp://jama.ama-assn.orgen
dc.identifier.bibliographicCitationJAMA: The Journal of the American Medical Association 2005 September 21; 294(11): 1359-1366en
dc.identifier.urihttp://hdl.handle.net/10822/507594en
dc.description.abstractMost tissues in complex metazoans contain a rare subset of cells that, at the single-cell level, can self-renew and also give rise to mature daughter cells. Such stem cells likely in development build tissues and are retained in adult life to regenerate them. Cancers and leukemias are apparently not an exception: rare leukemia stem cells and cancer stem cells have been isolated that contain all of the tumorigenicity of the whole tumor, and it is their properties that will guide future therapies. None of this was apparent just 20 years ago, yet this kind of stem cell thinking already provides new perspectives in medical science and could usher in new therapies. Today, political, religious, and ethical issues surround embryonic stem cell and patient-specific pluripotent stem cell research and are center stage in the attempts by governments to ban these fields for discovery and potential therapies. These interventions require physicians and physician- scientists to determine for themselves whether patient welfare or personal ethics will dominate in their practices, and whether all aspects of stem cell research can be pursued in a safe and regulated fashion.en
dc.formatArticleen
dc.languageengen
dc.source288290en
dc.subjectCanceren
dc.subjectCellsen
dc.subjectEthicsen
dc.subjectLeukemiaen
dc.subjectLifeen
dc.subjectMedicineen
dc.subjectPhysiciansen
dc.subjectRegenerative Medicineen
dc.subjectResearchen
dc.subjectScienceen
dc.subjectStem Cellsen
dc.subject.classificationGenetics, Molecular Biology and Microbiologyen
dc.subject.classificationArtificial and Transplanted Organs or Tissuesen
dc.subject.classificationResearch on Special Populationsen
dc.subject.classificationResearch on Embryos and Fetusesen
dc.titleStem cell research: paths to cancer therapies and regenerative medicineen
dc.provenanceDigital citation created by the Bioethics Research Library, Georgetown University, for the National Information Resource on Ethics and Human Genetics, a project funded by the United States National Human Genome Research Instituteen
dc.provenanceDigital citation migrated from OpenText Livelink Discovery Server database named GenETHX to DSpace collection GenETHX hosted by Georgetown Universityen


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