Preimplantation HLA typing: having children to save our loved ones
Journal of Medical Ethics 2005 October; 31(10): 582-586
Preimplantation tissue typing has been proposed as a method for creating a tissue matched child that can serve as a haematopoietic stem cell donor to save its sick sibling in need of a stem cell transplant. Despite recent promising results, many people have expressed their disapproval of this method. This paper addresses the main concerns of these critics: the risk of preimplantation genetic diagnosis (PGD) for the child to be born; the intention to have a donor child; the limits that should be placed on what may be done to the donor child, and whether the intended recipient can be someone other than a sibling. The author will show that these concerns do not constitute a sufficient ground to forbid people to use this technique to save not only a sibling, but also any other loved one's life. Finally, the author briefly deals with two alternative scenarios: the creation of a human leukocyte antigen (HLA) matched child as an insurance policy, and the banking of HLA matched embryos.
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Faden, Ruth; Donovan, Peter J.; Harris, John; Lovell-Badge, Robin; Mathews, Debra J.H.; Savulescu, Julian; Azariah, Jayapual; Benvenisty, Nissim; Bok, Hilary; Brunelli, Silvia; Campbell, Philip; Chan, Sarah; Cheng, Linzahao; Coles, David; Devolder, Katrien; Finkel, Julia; Friele, Minou; Heyd, David; Honey, Colin; Hyun, Insoo; Isasi, Rosario M.; Kyu Won, Jung; Liao, S. Matthew; McLaren, Anne; Mori, Maurizio; Munthe, Christian; Murdoch, Alison; Nakatsuji, Norio; O'Toole, Chris; Panicker, Mitradas M.; Patterson, Mark; Pedersen, Roger A.; Pera, Martin Frederick; Purnell, Beverly A.; Regenberg, Alan; Qui, Ren-Zong; Romeo-Casabona, Carlos M.; Salter, Brian; Samuelson, Taylor; Santalo, Josep; Saunders, Rhodri; Sheng, Hui Z.; Skene, Loane; Solter, Davor; Stacey, Glyn; Stubing, William C.; Sugarman, Jeremy; Sugden, Andrew M.; Van Steirteghem, Andre; Wallace, Susan E.; Walters, LeRoy B.; Zambidis, Elias T. (The Hinxton Group. An international consortium on stem cells, ethics and law, 2006-02-24)