DIANA anomalies: criteria for generating human pluripotent stem cells without embryos
National Catholic Bioethics Quarterly 2007 Summer; 7(2): 315-335
Ethical concerns are motivating the search for alternative methods to obtain pluripotent stem cells without destroying human embryos. The supporters of these methods stress the importance of ensuring that the biological entities used in these alternative methods are not "disabled or sick human embryos." In this article the authors argue that biological entities bearing anomalies or alterations that directly inhibit the appearance of neural activity (DIANA anomalies) share the moral status of human organisms fulfilling the clinical criteria for brain death. By contrast, in the absence of DIANA anomalies, the moral status of a person cannot be denied.
Brain; Brain Death; Cells; Death; Embryos; Methods; Moral Status; Pluripotent Stem Cells; Stem Cells; Religious Ethics; Value / Quality of Life; In Vitro Fertilization and Embryo Transfer; Genetics, Molecular Biology and Microbiology; Research on Special Populations; Research on Embryos and Fetuses; Definition of Death;
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Federal funding for research involving human pluripotent stem cells [". . . in response to your request for a legal opinion of whether federal funds may be used for research conducted with human pluripotent stem cells derived from embryos created by in vitro fertilization or from primordial germ cells isolated from the tissue of non-living fetuses."] Rabb, Harriet S.; United States. Department of Health and Human Services. Office of the General Counsel (1999-01-15)