The case of the missing heritability. When scientists opened up the human genome, they expected to find the genetic components of common traits and diseases. But they were nowhere to be seen.
Nature 2008 November 6; 456(7218): 18-21
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"Are we there yet?": deciding when one has demonstrated specific genetic causation in complex diseases and quantitative traits Page, Grier P.; George, Varghese; Go, Rodney C.; Page, Patricia Z.; Allison, David B. (2003-10)