New Ventures Aim to Put Farms in Vanguard of Drug Production: Altering Gene Structure to "Grow" Medicines in Common Crops
New York Times 2000 May 14; p. A1, A26
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Histone ADP-ribosylation by Poly(ADP-ribose) Polymerase 1 (PARP1) Facilitates Inflammatory Gene Transcription by Directly Altering Nucleosome Structure Martinez-Zamudio, Ricardo Ivan (Georgetown University, 2012)The packaging of DNA into nucleosomes imposes obstacles to gene transcription as they limit the accessibility of DNA to the transcription machinery. As such, the modulation of nucleosome structure by histone-modifying and ...