The twin questions of personalized medicine: who are you and whom do you most resemble?
Kohane, Isaac S.
Genome Medicine 2009 January 20; 1(1): 4
ABSTRACT: Personalized medicine is typically described as the use of molecular or genetic characteristics to customize therapy. This perspective at best provides an incomplete model of the patient and at worst can lead to grossly inappropriate practices. Personalization of medicine requires two characterizations: a well-grounded understanding of who the patient is and an equally robust understanding of the subpopulation that most resembles that patient in the context of the decisions at hand. These characterizations are readily represented probabilistically and can be used to drive decision-making in a rational manner that maximizes the positive outcomes for the patient.
Permanent LinkFind Full Text at Georgetown University Library
Full Text from Publisher
Showing items related by title, author, creator and subject.
Kohane, Isaac S; Taylor, Patrick L (2010-06-23)Recent surveys about participation in cohort studies reconfirm that participants value and desire the return of research results to a degree that is out of step with the restrictive recommendations of various ethics advisory ...
Maintaining the Confidentiality of Medical Records Shared Over the Internet and the World Wide Web Rind, David M.; Kohane, Isaac S.; Szolovits, Peter; Safran, Charles; Chueh, Henry C.; Barnett, G. Octo (1997-07-15)The Boston Electronic Medical Record Collaborative is working to develop a system that will use the World Wide Web to transfer computer-based patient information to clinicians in emergency departments. Maintaining adequate ...