Population screening for genetic disorders in the 21st century: evidence, economics, and ethics.
Public Health Genomics 2010 (2009 December); 13(2): 106-115
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Grosse, S.D.; Rogowski, W.H.; Ross, L.F.; Cornel, M.C.; Dondorp, W.J.; Khoury, M.J. (2010)BACKGROUND: Proposals for population screening for genetic diseases require careful scrutiny by decision makers because of the potential for harms and the need to demonstrate benefits commensurate with the opportunity cost ...
Ethical Implications and Practical Considerations of Ethnically Targeted Screening for Genetic Disorders: The Case of Hemoglobinopathy Screening Hinton, Cynthia F; Grant, Althea M; Grosse, Scott D (2011-08)The prevalence of hemoglobinopathies differs among populations due to genetic differences and due to the protective effects of the heterozygote (carrier) state against malaria. Because of the difference in genetic distribution, ...