Ethical issues of unrelated hematopoietic stem cell transplantation in adult thalassemia patients.
La Nasa, Giorgio
BMC medical ethics 2011 March 8; 12: 4
Beta thalassemia major is a severe inherited form of hemolytic anemia that results from ineffective erythropoiesis. Allogenic hematopoietic stem cell transplantation (HSCT) remains the only potentially curative therapy. Unfortunately, the subgroup of adult thalassemia patients with hepatomegaly, portal fibrosis and a history of irregular iron chelation have an elevated risk for transplantation-related mortality that is currently estimated to be about 29 percent.
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