Human behavior and infectious disease are related in a dynamic feedback loop. This integral and ubiquitous relationship is often ignored in epidemiological modeling, leading to findings that overlook a crucial element in ...

Inositol pyrophosphates are high energy signaling molecules found across eukaryotes that are important for diverse cellular processes like phosphate homeostasis, the immune response, fungal pathogenicity, endocytosis, ...

Staphylococcus aureus infections impose a serious economic burden on healthcare facilities and patients because of the emergence of strains resistant to last-line antibiotics. Understanding the physiological processes ...

Hearing depends on a properly formed inner ear to transmit sound information to the brain. Purinergic signaling has been implicated in the development of the inner ear, especially with regard to the cochlea. P2rx3 receptors ...

α-Synuclein is a 140-amino acid protein highly expressed in presynaptic terminals and is also associated with Lewy body pathology found in Lewy Body Dementia (LBD) and Parkinson’s disease (PD) patients. We and others have ...

Neurogenesis is a tightly controlled developmental process through which neural progenitor cells progress to committed neurons. While the SoxB1 transcription factors are well characterized to have functions in the induction ...

Holometabolous insects, those that undergo complete metamorphosis, owe their tremendous evolutionary success in large part to an efficient division of labor between a larval phase that focuses on feeding, and an adult phase ...

Individuals within a population differ in behavior along both social and ecological axes. These differences are proposed to be governed by niche theory at the individual level, but empirical evidence is sparse, especially ...

Current therapies to improve hearing, including hearing aids and cochlear implants, require intact and functional auditory neurons. Within the inner ear, the primary auditory neurons, called spiral ganglion neurons (SGNs), ...

Astrobiology is the study of the “living universe,” which includes the study of the origin of lifeas well as its evolution and distribution on Earth and beyond. Prime candidates for alien life include the icy moons of the ...