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Identification of A-to-I RNA Editing Sites in the Honey Bee (Apis mellifera) Brain Using RNAseq Data
(Georgetown University, 2014)
RNA editing is a post-transcriptional modification process that leads to addition, substitution and deletion of certain bases in RNA molecules, and accordingly alters their biological properties. As the most widespread ...
SIW14 IS A NOVEL 5-DIPHOSPHOINOSITOL PENTAKISPHOSPHATE (5PP-IP5) PHOSPHATASE THAT NEGATIVELY REGULATES THE STRESS RESPONSE
(Georgetown University, 2016)
Inositol pyrophosphates are high energy signaling molecules involved in cellular processes such as energetic metabolism, telomere maintenance, vesicle trafficking, and the stress response. While the inositol kinases ...
LESS IS MORE: THE IMPLICATIONS OF GENOMIC MINIMALISM ON THE REGULATION OF GENE EXPRESSION IN THE PARASITE GIARDIA LAMBLIA
(Georgetown University, 2012)
<italic>Giardia lamblia<italic> is one of the most common eukaryotic intestinal parasites in the world. A theme of simplified cellular machinery characterizes much of its biology with interesting consequences: a greatly ...
Grf10 Transcription Factor Coordinates Nutrient Assimilation, Metabolism and Morphogenesis in Candida albicans
(Georgetown University, 2018)
Candida albicans is a commensal of the human microbiome and a major human fungal pathogen. Morphogenesis and metabolism are key attributes that allow C. albicans to thrive and infect the human host. Grf10, a homeodomain-containing ...
Assessing the Function of SOX21 in Xenopus laevis Neurogenesis: Exploring Homeolog Sub-Functionalization
(Georgetown University, 2021)
Neurogenesis is a tightly controlled developmental process through which neural progenitor cells progress to committed neurons. While the SoxB1 transcription factors are well characterized to have functions in the induction ...
The Role of the Nutrient Sensor CodY in Regulating Nuclease Production and Extracellular DNA Metabolism in Staphylococcus Aureus
(Georgetown University, 2019)
As an opportunistic pathogen, Staphylococcus aureus is a leading cause of skin and soft tissue infections. The success of S. aureus as a pathogen stems from its ability to produce a plethora of virulence factors that aid ...
Pseudophosphatases Enhance Siw14, an Inositol Pyrophosphate Phosphatase that Negatively Regulates the Environmental Stress Response through Msn2
(Georgetown University, 2021)
Inositol pyrophosphates are high energy signaling molecules found across eukaryotes that are important for diverse cellular processes like phosphate homeostasis, the immune response, fungal pathogenicity, endocytosis, ...
Assessing the Function of SOX21 in Xenopus laevis Neurogenesis: Exploring Homeolog Sub-Functionalization
(Georgetown University, 2021)
Neurogenesis is a tightly controlled developmental process through which neural progenitor cells progress to committed neurons. While the SoxB1 transcription factors are well characterized to have functions in the induction ...