Browsing Graduate Theses and Dissertations - Chemistry by Title
Now showing items 2-21 of 152
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A Story of a Scientist: A Researcher, Mentor, Teacher, Leader, and Advocate
(Georgetown University, 2021)In efforts to find renewable and sustainable alternatives to gasoline in transportation vehicles, scientists have been studying the design and use of fuel cells. In a fuel cell, a fuel undergoes a reaction that generates ... -
A Switch In Folding Energy Landscape Governs the Allosteric Activation of Protein Kinase A
(Georgetown University, 2018)Protein kinases are dynamic molecular switches that are responsible for the regulation of many cellular processes. Mutations, deletions, or gene fusions in protein kinase have been associated with the development of many ... -
Accelerated Asymmetric Reaction Screening and Sensing of Biomolecules Using Small Molecular Probes
(Georgetown University, 2020)Chiroptical sensing has recently gained interest as a rapid technique for screening asymmetric reactions and quantification of important biomolecules. In this thesis an array of probes and chiroptical sensing strategies ... -
Activation of PKA via Asymmetric Allosteric Coupling of Structurally Conserved Cyclic Nucleotide Binding Domains
(Georgetown University, 2019)Cyclic nucleotide binding (CNB) domains are universally conserved signaling modules that regulate the activities of diverse protein functions. While high-resolution structures of CNB domains have been available for decades, ... -
Adhesion Properties and Phase Transformations of Uric Acid Crystals
(Georgetown University, 2012)Uric acid, a product of protein metabolism, is the most abundant organic component in human kidney stones. At least six different crystalline phases of uric acid have been identified in kidney stones. Anhydrous uric acid ... -
Adiabatic Proton-Coupled Charge-Transfer Reactions and Photochemistry of N,N-Dimethyl-3-arylpropan-1-ammonium Salts
(Georgetown University, 2016)The coupling of proton and electron transfers in concerted or sequential processes is of central importance to many biochemical and catalytic reactions. In this context, proton-coupled electron transfer reactions are ... -
ALKANE CHALCOGENOLATE - PROTECTED METAL NANOPARTICLES: SYNTHESIS, FORMATIONS, CHARACTERIZATIONS, AND INTERFACE INVESTIGATIONS
(Georgetown University, 2012)Organo selenolate - protected gold (Au) nanoparticles (NPs) have shown high potential for nanoelectronic applications, where electrochemical studies are crucial for understanding the charge transfer mechanism between the ... -
Alkanethiolate-Protected Silver Nanoparticles and Clusters: Characterization, Synthesis Optimization and Formation Mechanism Investigation
(Georgetown University, 2016)The primary objective of this thesis research was to investigate reaction process of silver nanoparticle (Ag NP) and nanocluster synthesis; to develop facile and efficient way to synthesize small and homogeneous silver ... -
Altering Physical Properties of High-Energy Materials and Other Small Molecules Through Template-Directed and Co-Crystallization Methods
(Georgetown University, 2014)The quality and performance of organic materials shape our everyday life. Organic crystals have the propensity to be polymorphic, and properties between forms may be drastically different. Crystallization of polymorphic ... -
Analysis of Parasite Chloroquine Resistance Transporter Proteins and Their Roles in Drug Resistance Phenomena
(Georgetown University, 2020)The development of drug resistance in Plasmodium parasites continues to present a major challenge in abating the global malaria burden. It has been well established that mutations in the Plasmodium falciparum chloroquine ... -
ANALYSIS OF PLASMODIUM FALCIPARUM CHLOROQUINE RESISTANCE TRANSPORTER ISOFORMS
(Georgetown University, 2015)Mutations in the Plasmodium falciparum chloroquine resistance transporter (PfCRT) have been shown to be central to the molecular mechanism of quinoline antimalarial drug resistance. However, additional facets to resistance ... -
Analysis of the cellular and molecular mechanisms of Chloroquine Resistance in Plasmodium Falciparum
(Georgetown University, 2009) -
Applications of Asymmetric Catalysis and Green Chemistry Principles Towards the Synthesis of Chiral Multifunctional Alcohols and Organofluorine Compounds
(Georgetown University, 2018)Asymmetric reaction development and synthesis of chiral building blocks are fundamental to the pharmaceutical and agrochemical sciences. Specifically, the field of asymmetric catalysis has amassed a growing body of reactions ... -
An approximate multipole expansion for molecular interactions
(Georgetown University, 2010) -
Assessing Antimalarial Cidality in Plasmodium falciparum Parasites
(Georgetown University, 2014)The rise of resistance to commonly used antimalarial medications, such as chloroquine, has exacerbated a global health burden. Years of study of chloroquine resistance has focused on low concentrations of drug that result ... -
ASYMMETRIC CATALYSIS AND SENSING WITH RIGID C2-SYMMETRIC LIGANDS AND DEVELOPMENT OF HEME-TARGETED ANTIMALARIALS
(Georgetown University, 2009)The first general procedure for the ligand-catalyzed nucleophilic addition of diethylzinc to trifluoromethyl ketones was developed. A range of 2-aryl-1,1,1-trifluorobutan-2-ols have been prepared in up to 99% yield using ... -
Beta-Diketiminato Copper Complexes for C-H Bond Functionalization
(Georgetown University, 2014)C-H amination is an attractive methodology for constructing C-N bonds from seemingly unreactive C-H bonds. This process reduces group manipulations and reaction by-products. C-H amination catalysts are usually rhodium and ... -
Beta-diketiminato copper complexes in C-H bond amination
(Georgetown University, 2010) -
Beta-diketiminato nickel and copper complexes in C-N bond formation and N-O bond activation
(Georgetown University, 2011) -
Bifunctional Hydrogenation Catalysis in Aqueous and Formic Acid/Triethylamine Media
(Georgetown University, 2012)Catalytic hydrogenation of organic compounds with molecular hydrogen is fast and efficient, but requires high gas pressures. Recently, there has been a revival in the field of catalytic transfer hydrogenation using formic ...
