Browsing Graduate Theses and Dissertations - Chemistry by Title
Now showing items 38-57 of 152
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Dehydration and Dopant Effects in Nucleic Acid Hydrates
(Georgetown University, 2017)The dehydration mechanism and the inclusion of molecular dyes (dopants) in two nucleic acid hydrates, thymine and cytosine, were investigated. Thymine hydrate (TH) was identified as a modulated system which undergoes a ... -
Design and Synthesis of Aryl Amphiphiles to Control the Growth of π-Conjugated Microcrystals along the π-Stack Direction
(Georgetown University, 2021)Photonic integrated circuits (PICs) are capable of overcoming the numerous limitations facing traditional integrated circuits, such as the heat generated by the fast movement of electrons and the size limitations. However, ... -
Design, Synthesis, and Applications of Stereodynamic Chirality Probes
(Georgetown University, 2015)Novel stereodynamic chirality probes were developed for enantioselective sensing of chiral compounds, utilizing the concepts of dynamic covalent chemistry and metal-ligand coordination. Upon interaction with a chiral ... -
Design, Synthesis, and High-throughput Applications of Small Molecule Chiroptical Probes
(Georgetown University, 2020)This work showcases several chirality sensors that undergo covalent bond formation with small amine-containing molecules and thus produce a circular dichroism (CD) signal that can be used for chiroptical analysis of the ... -
DEVELOPMENT AND CHARACTERIZATION OF CONDUCTING POLYMER MODIFIED ELECTRODES FOR NEUROLOGICAL APPLICATIONS
(Georgetown University, 2011)Electrodes have the potential to be applied to neurological signal detection, neurotransmitter detection, or neurological stimulation, but there are many factors to consider. These factors include the electrochemical ... -
Development of Enantioselective Agents and Heme-Targeted Antimalarials
(Georgetown University, 2011)Several chiral 3,5-dinitrobenzoyl-derived amides were prepared and applied in enantioselective NMR analysis of protected amines. It was found that (R)-N-(1-(naphthalen-1-yl)ethyl)-3,5-dinitrobenzamide is a very effective ... -
Development of Optical Methods for Sensing of Chiral Compounds Using Organometallic Probes
(Georgetown University, 2019)With the advent of high-throughput experimentation, hundreds of asymmetric reactions can be conducted in parallel. Traditional methods used to analyze asymmetric reaction mixtures are intrinsically serial, time-consuming ... -
Development of Plasma-based Ion Sources for Elemental Quantification and Non-targeted Analysis of Chlorinated and Fluorinated Compounds
(Georgetown University, 2021)The expanding use of organochlorines and organofluorines in pesticides, pharmaceuticals, and industrial applications, along with environmental contamination by these compounds require the development of analytical methods ... -
Directed Crystal Growth and Solid-State Analysis of the Secondary Explosives RDX and HMX
(Georgetown University, 2011)Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) and octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine (HMX) are two of the most commonly used secondary explosives in military and industrial applications. For use as explosives, ... -
Dynamic Aspects of Sterically-Graded Pyrenyl Molecules and Polymer Chains Probed by Excited State Charge- and Electron-Transfer Interactions
(Georgetown University, 2017)Charge- and electron-transfer processes are among the simplest and most important class of chemical reactions because they involve directly no bond making or bond breaking. They play a key role in photosynthesis, molecular ... -
Dynamics and Molecular-Level Control of Solid State Transformations in Molecular Hydrates
(Georgetown University, 2021)Organic solids are pervasive in the fine chemical industry. The diversity of solid state structures continues to expand with chemical and engineering efforts to design, synthesize, and use fit-for-purpose molecular materials. ... -
Electrochemical Studies and In Situ Electrochemical Nuclear Magnetic Resonance Investigations on Platinum-based Bimetallic Electrocatalysts for Direct Methanol Fuel Cells
(Georgetown University, 2009)Two parallel objectives of this thesis research are 1) to investigate the electrocatalytic activities of Pt-based bimetallic nanoparticles (NPs) towards methanol (MeOH) electro-oxidation reaction (MOR), carbon monoxide ... -
Electron Transfer and Assembly in Fe-S Proteins
(Georgetown University, 2011)The iron-sulfur (Fe-S) proteins are a major class of metalloproteins, with metal sites consisting of varying numbers of iron and sulfur atoms. Most Fe-S proteins are electron transfer proteins involved in processes such ... -
Enhanced Analytical Capabilities and Fundamental Insights into Ion Formation In Pulsed Nano-Electrospray Ionization
(Georgetown University, 2020)The unrivaled ability of electrospray ionization (ESI) techniques to generate gaseous ions has inspired the development of new approaches to bolster the analytical utility in mass spectrometric (MS) and ion mobility (IM) ... -
Enhanced Elemental Mass Spectrometry of Fluorine and Chlorine via Chemical Ionization in the Afterglow of an Inductively Coupled Plasma
(Georgetown University, 2021)There is an increasing need for trace-level analysis of fluorinated and chlorinated compounds in complex samples due to their prevalence among pharmaceuticals and environmental and food contaminants. Importantly, elemental ... -
Enhancing Forensic Evidential Value of Fibers via Single-Fiber Detection and Classification of Fluorinated Oil-and-Water-Repellent Fabric Coatings
(Georgetown University, 2021)Fibers are a common form of forensic evidence, however, they cannot be attributed to a single source because of the prevalence of fibers with common attributes. Accordingly, fibers are assigned to a class based on their ... -
Enzymes Under Pressure
(Georgetown University, 2018)One of the most interesting questions about piezophiles (pressure-loving) is why enzymes from piezophiles are active at much higher pressures than the homologous enzymes from mesophiles (normal-loving). To study pressure ... -
Exploiting Structural Disorder to Enhance Small Molecule Inhibition of the Oncoprotein c-Myc DImerization with its Partner Max
(Georgetown University, 2009)The transcription factor c-Myc, in its normal function, is involved in cell cycle regulation. The uncontrolled cell proliferation consequent to c-Myc deregulation is typical of cancer and neoplastic diseases. Most known ... -
Exploring the Structure-Activity Relationship of Platinum and Platinum-based Electro-catalysts for the Methanol Electro-oxidation
(Georgetown University, 2013)This dissertation focuses on fundamental studies to improve the understanding of surface interactions on Pt electro-catalysts using the methanol oxidation reaction (MOR) as the model surface sensitive reaction. Advances ... -
From Pendant Chains to π-Face Blocking Straps: Enhancing the Role of Side-Chains in Controlling Mechanicla and Optical Properties of π-Conjugated Polymers
(Georgetown University, 2021)This dissertation is a body of research focusing on conjugated polymers and smallmolecules for organic electronics. The projects in this work are aimed at understanding the interplay between structure and function by ...
