Browsing Graduate Theses and Dissertations - Chemistry by Title
Now showing items 49-68 of 152
-
Electrochemical Studies and In Situ Electrochemical Nuclear Magnetic Resonance Investigations on Platinum-based Bimetallic Electrocatalysts for Direct Methanol Fuel Cells
(Georgetown University, 2009)Two parallel objectives of this thesis research are 1) to investigate the electrocatalytic activities of Pt-based bimetallic nanoparticles (NPs) towards methanol (MeOH) electro-oxidation reaction (MOR), carbon monoxide ... -
Electron Transfer and Assembly in Fe-S Proteins
(Georgetown University, 2011)The iron-sulfur (Fe-S) proteins are a major class of metalloproteins, with metal sites consisting of varying numbers of iron and sulfur atoms. Most Fe-S proteins are electron transfer proteins involved in processes such ... -
Enhanced Analytical Capabilities and Fundamental Insights into Ion Formation In Pulsed Nano-Electrospray Ionization
(Georgetown University, 2020)The unrivaled ability of electrospray ionization (ESI) techniques to generate gaseous ions has inspired the development of new approaches to bolster the analytical utility in mass spectrometric (MS) and ion mobility (IM) ... -
Enhanced Elemental Mass Spectrometry of Fluorine and Chlorine via Chemical Ionization in the Afterglow of an Inductively Coupled Plasma
(Georgetown University, 2021)There is an increasing need for trace-level analysis of fluorinated and chlorinated compounds in complex samples due to their prevalence among pharmaceuticals and environmental and food contaminants. Importantly, elemental ... -
Enhancing Forensic Evidential Value of Fibers via Single-Fiber Detection and Classification of Fluorinated Oil-and-Water-Repellent Fabric Coatings
(Georgetown University, 2021)Fibers are a common form of forensic evidence, however, they cannot be attributed to a single source because of the prevalence of fibers with common attributes. Accordingly, fibers are assigned to a class based on their ... -
Enzymes Under Pressure
(Georgetown University, 2018)One of the most interesting questions about piezophiles (pressure-loving) is why enzymes from piezophiles are active at much higher pressures than the homologous enzymes from mesophiles (normal-loving). To study pressure ... -
Exploiting Structural Disorder to Enhance Small Molecule Inhibition of the Oncoprotein c-Myc DImerization with its Partner Max
(Georgetown University, 2009)The transcription factor c-Myc, in its normal function, is involved in cell cycle regulation. The uncontrolled cell proliferation consequent to c-Myc deregulation is typical of cancer and neoplastic diseases. Most known ... -
Exploring the Structure-Activity Relationship of Platinum and Platinum-based Electro-catalysts for the Methanol Electro-oxidation
(Georgetown University, 2013)This dissertation focuses on fundamental studies to improve the understanding of surface interactions on Pt electro-catalysts using the methanol oxidation reaction (MOR) as the model surface sensitive reaction. Advances ... -
From Pendant Chains to π-Face Blocking Straps: Enhancing the Role of Side-Chains in Controlling Mechanicla and Optical Properties of π-Conjugated Polymers
(Georgetown University, 2021)This dissertation is a body of research focusing on conjugated polymers and smallmolecules for organic electronics. The projects in this work are aimed at understanding the interplay between structure and function by ... -
Functionalized 1,8-Diarylnaphthalenes: Applications in Enantioselective Sensing and Stereoselective Cycloadditions
(Georgetown University, 2011)The unique structure of 1,8-diarylnaphthalenes provides an excellent opportunity to design sensors with a chromophoric binding pocket and the ability to transform a binding event with a chiral substrate into a strong and ... -
FUNDAMENTAL INVESTIGATION AND NOVEL APPLICATIONS OF ELECTROSPRAY AND GAS-PHASE IONIZATIONS
(Georgetown University, 2015)Mass spectrometry (MS) is an analytical technique used for identifying and quantitating the chemical constituents of materials. For mass spectrometric analysis, analytes must be charged (i.e. be ionized) and be in the gas ... -
Gels from Borate-Crosslinked Partially Hydrolyzed Poly(vinyl acetate)s: Characterization of Physical and Chemical Properties and Applications in Art Conservation
(Georgetown University, 2013)The formation of gel-like dispersions from borate-crosslinked, partially hydrolyzed poly(vinyl acetate)s (xPVAc, where x is the percent of hydrolysis) and their application for treatment of art is explored. It is shown ... -
The Genetically Encodable Oriented Adsorption of Proteins onto Gold Nanoparticles
(Georgetown University, 2011)Many assays rely upon immobilizing proteins onto gold surfaces. Therefore, simple, stable and specific methods for protein immobilization are needed for the development of applications which rely on the oriented attachment ... -
Growth and adhesion properties of monosodium urate monohydrate (MSU) crystals
(Georgetown University, 2011) -
Harnessing Noncovalent Interactions towards the Stabilization of Actinide Complexes and Clusters
(Georgetown University, 2020)The chemical and physical properties of the actinides are exploited in applications ranging from nuclear energy to radiopharmaceuticals, with the aqueous behavior of these metal cations playing a critical role in both ... -
Heterogenization of Metallocyclopentadienyl Precatalysts Through Ligand Functionalization for Incorporation into Metal-Organometallic Frameworks
(Georgetown University, 2019)Heterogenization of metallocyclopentadienyl ([CpxMII]+, M = Ru, Fe) precatalysts is explored through introduction to Metal-Organic Frameworks (MOFs) using [CpxMII]+-functionalized organic ligands. Such precatalytic moieties ... -
Hydrogels and Organogels from Partially Hydrolyzed Poly(vinyl acetates) and Boron-based Crosslinkers: Development, Characterization, and Application to the Conservation of Art
(Georgetown University, 2017)Soft, peelable hydrogels and organogels formed from partially hydrolyzed poly(vinyl acetate)s and different crosslinkers have been developed, characterized, and evaluated for cleaning treatments on works of art. Partially ... -
Interactions of quinolinols, peptides and SNAP-25 with the protease domain of botulinum neurotoxin A
(Georgetown University, 2010) -
Investigating Potential Mechanisms of Cytocidal Drug Resistance in Plasmodium falciparum
(Georgetown University, 2013)By quantifying antimalarial cytocidal activities (measured as LD50s) and comparing them to cytostatic activities (measured as IC50s), Paguio et al., 2011 showed a clear difference between some drug activities at different ... -
Investigating the Cytostatic and Cytocidal Mechanisms of Quinoline Drug Resistance in Plasmodium falciparum
(Georgetown University, 2013)Efficacy of, mechanisms of action of, and resistance to chemotherapeutic agents targeted against the malarial parasite Plasmodium falciparum have historically been defined by quantifying cytostatic potency or growth-inhibition. ...
