Browsing Graduate Theses and Dissertations - Chemistry by Title
Now showing items 57-76 of 152
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From Pendant Chains to π-Face Blocking Straps: Enhancing the Role of Side-Chains in Controlling Mechanicla and Optical Properties of π-Conjugated Polymers
(Georgetown University, 2021)This dissertation is a body of research focusing on conjugated polymers and smallmolecules for organic electronics. The projects in this work are aimed at understanding the interplay between structure and function by ... -
Functionalized 1,8-Diarylnaphthalenes: Applications in Enantioselective Sensing and Stereoselective Cycloadditions
(Georgetown University, 2011)The unique structure of 1,8-diarylnaphthalenes provides an excellent opportunity to design sensors with a chromophoric binding pocket and the ability to transform a binding event with a chiral substrate into a strong and ... -
FUNDAMENTAL INVESTIGATION AND NOVEL APPLICATIONS OF ELECTROSPRAY AND GAS-PHASE IONIZATIONS
(Georgetown University, 2015)Mass spectrometry (MS) is an analytical technique used for identifying and quantitating the chemical constituents of materials. For mass spectrometric analysis, analytes must be charged (i.e. be ionized) and be in the gas ... -
Gels from Borate-Crosslinked Partially Hydrolyzed Poly(vinyl acetate)s: Characterization of Physical and Chemical Properties and Applications in Art Conservation
(Georgetown University, 2013)The formation of gel-like dispersions from borate-crosslinked, partially hydrolyzed poly(vinyl acetate)s (xPVAc, where x is the percent of hydrolysis) and their application for treatment of art is explored. It is shown ... -
The Genetically Encodable Oriented Adsorption of Proteins onto Gold Nanoparticles
(Georgetown University, 2011)Many assays rely upon immobilizing proteins onto gold surfaces. Therefore, simple, stable and specific methods for protein immobilization are needed for the development of applications which rely on the oriented attachment ... -
Growth and adhesion properties of monosodium urate monohydrate (MSU) crystals
(Georgetown University, 2011) -
Harnessing Noncovalent Interactions towards the Stabilization of Actinide Complexes and Clusters
(Georgetown University, 2020)The chemical and physical properties of the actinides are exploited in applications ranging from nuclear energy to radiopharmaceuticals, with the aqueous behavior of these metal cations playing a critical role in both ... -
Heterogenization of Metallocyclopentadienyl Precatalysts Through Ligand Functionalization for Incorporation into Metal-Organometallic Frameworks
(Georgetown University, 2019)Heterogenization of metallocyclopentadienyl ([CpxMII]+, M = Ru, Fe) precatalysts is explored through introduction to Metal-Organic Frameworks (MOFs) using [CpxMII]+-functionalized organic ligands. Such precatalytic moieties ... -
Hydrogels and Organogels from Partially Hydrolyzed Poly(vinyl acetates) and Boron-based Crosslinkers: Development, Characterization, and Application to the Conservation of Art
(Georgetown University, 2017)Soft, peelable hydrogels and organogels formed from partially hydrolyzed poly(vinyl acetate)s and different crosslinkers have been developed, characterized, and evaluated for cleaning treatments on works of art. Partially ... -
Interactions of quinolinols, peptides and SNAP-25 with the protease domain of botulinum neurotoxin A
(Georgetown University, 2010) -
Investigating Potential Mechanisms of Cytocidal Drug Resistance in Plasmodium falciparum
(Georgetown University, 2013)By quantifying antimalarial cytocidal activities (measured as LD50s) and comparing them to cytostatic activities (measured as IC50s), Paguio et al., 2011 showed a clear difference between some drug activities at different ... -
Investigating the Cytostatic and Cytocidal Mechanisms of Quinoline Drug Resistance in Plasmodium falciparum
(Georgetown University, 2013)Efficacy of, mechanisms of action of, and resistance to chemotherapeutic agents targeted against the malarial parasite Plasmodium falciparum have historically been defined by quantifying cytostatic potency or growth-inhibition. ... -
Investigating the Fundamental Optical Properties of Single Zinc Oxide Nanorods as an Optical Waveguide for Biomedical Applications
(Georgetown University, 2020)The superior optical properties of zinc oxide nanorods (ZnO NRs) have continued to promote their broad use in photonics, light detecting, and biosensing applications due to their waveguiding properties. One particularly ... -
Investigating the Interconversion of Dinitrogen and Ammonia: An Interrogation of Secondary Coordination Sphere Influences on Critical Intermediates
(Georgetown University, 2021)The near thermoneutral interconversion of dinitrogen (N2) and ammonia (NH3) sustains life and society on Earth. Altogether, the N2 / NH3 interconversion involves a nexus of high energy intermediates connected through ... -
Investigating the Mechanism of Action of Artemisinin Antimalarials and the Role of Ferriprotoporphyrin IX Heme
(Georgetown University, 2019)Malaria continues to be a serious threat to human health. The current first-line treatment -
INVESTIGATION OF FREQUENCY-INDEPENDENT IMPEDANCE BEHAVIOR IN CONDUCTING POLYMERS
(Georgetown University, 2010)Biocompatibility and low, frequency-independent impedance are critical in the design of electrodes for bioelectric signal sensing applications. These conditions could be regarded as the minimum requirements in order to ... -
INVESTIGATION OF PROTEIN AND SMALL-MOLECULE SELF-ASSOCIATION IN THE CONTEXT OF C-MYC/MAX INHIBITION
(Georgetown University, 2016)The intrinsically disordered c-Myc oncoprotein is deregulated in ~70% of human cancers and is considered a promising but challenging drug target. To regulate transcription, c-Myc undergoes coupled folding and binding with ... -
Lewis acid assisted metal-ligand bifunctional hydrogenation of amides
(Georgetown University, 2009) -
Luminescent Bismuth(III)-Organic Compounds: Synthesis and Spectroscopic Properties
(Georgetown University, 2019)This work focuses on the synthesis and characterization of bismuth(III)-organic compounds with an eye towards developing structure-photoluminescent behavior relationships in bismuth-based materials. Twenty-eight compounds ... -
Macrosolute effects on nucleic acids
(Georgetown University, 2008)
