Browsing Graduate Theses and Dissertations - Chemistry by Title
Now showing items 66-85 of 152
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Interactions of quinolinols, peptides and SNAP-25 with the protease domain of botulinum neurotoxin A
(Georgetown University, 2010) -
Investigating Potential Mechanisms of Cytocidal Drug Resistance in Plasmodium falciparum
(Georgetown University, 2013)By quantifying antimalarial cytocidal activities (measured as LD50s) and comparing them to cytostatic activities (measured as IC50s), Paguio et al., 2011 showed a clear difference between some drug activities at different ... -
Investigating the Cytostatic and Cytocidal Mechanisms of Quinoline Drug Resistance in Plasmodium falciparum
(Georgetown University, 2013)Efficacy of, mechanisms of action of, and resistance to chemotherapeutic agents targeted against the malarial parasite Plasmodium falciparum have historically been defined by quantifying cytostatic potency or growth-inhibition. ... -
Investigating the Fundamental Optical Properties of Single Zinc Oxide Nanorods as an Optical Waveguide for Biomedical Applications
(Georgetown University, 2020)The superior optical properties of zinc oxide nanorods (ZnO NRs) have continued to promote their broad use in photonics, light detecting, and biosensing applications due to their waveguiding properties. One particularly ... -
Investigating the Interconversion of Dinitrogen and Ammonia: An Interrogation of Secondary Coordination Sphere Influences on Critical Intermediates
(Georgetown University, 2021)The near thermoneutral interconversion of dinitrogen (N2) and ammonia (NH3) sustains life and society on Earth. Altogether, the N2 / NH3 interconversion involves a nexus of high energy intermediates connected through ... -
Investigating the Mechanism of Action of Artemisinin Antimalarials and the Role of Ferriprotoporphyrin IX Heme
(Georgetown University, 2019)Malaria continues to be a serious threat to human health. The current first-line treatment -
INVESTIGATION OF FREQUENCY-INDEPENDENT IMPEDANCE BEHAVIOR IN CONDUCTING POLYMERS
(Georgetown University, 2010)Biocompatibility and low, frequency-independent impedance are critical in the design of electrodes for bioelectric signal sensing applications. These conditions could be regarded as the minimum requirements in order to ... -
INVESTIGATION OF PROTEIN AND SMALL-MOLECULE SELF-ASSOCIATION IN THE CONTEXT OF C-MYC/MAX INHIBITION
(Georgetown University, 2016)The intrinsically disordered c-Myc oncoprotein is deregulated in ~70% of human cancers and is considered a promising but challenging drug target. To regulate transcription, c-Myc undergoes coupled folding and binding with ... -
Lewis acid assisted metal-ligand bifunctional hydrogenation of amides
(Georgetown University, 2009) -
Luminescent Bismuth(III)-Organic Compounds: Synthesis and Spectroscopic Properties
(Georgetown University, 2019)This work focuses on the synthesis and characterization of bismuth(III)-organic compounds with an eye towards developing structure-photoluminescent behavior relationships in bismuth-based materials. Twenty-eight compounds ... -
Macrosolute effects on nucleic acids
(Georgetown University, 2008) -
Magnetic and thermal studies of doped rare-earth chalcogenide nanostructures in solution and the solid-state
(Georgetown University, 2012)The europium chalcogenides (oxide, sulfide, selenide) are intrinsically ferromagnetic semiconductors. Research with these types of materials is motivated by applications in fields such as spintronics, which can take advantage ... -
MAGNETIC MESOPOROUS SILICA NANOPARTICLES AS POTENTIAL MRI CONTRAST AGENTS
(Georgetown University, 2016)Magnetic resonance imaging is a non-invasive diagnostic technique that utilizes native protons in biological samples to produce three-dimensional images. MR imaging relies on the native differences in relaxation time (T1 ... -
Mechanical Properties and Heterogeneous Growth of Uric Acid Crystals
(Georgetown University, 2019)The mechanical and structural properties of the anhydrous (UA) and the dihydrate (UAD) forms of uric acid crystals were investigated. UA, the more stable form, was found to have a substantially higher Young’s modulus and ... -
Mechanisms of SNAP-25 Association with Botulinum Neurotoxin Light Chain A and SNARE Proteins
(Georgetown University, 2012)Botulism neurotoxins (BoNTs), a family of neurotoxins produced by the anaerobic bacterium Clostridium botulinum, are the most poisonous biological toxins known to man and are listed as category A bioterrorism agents by the ... -
Mechanistic insight into the Brust-Schiffrin two-phase method for organochalcogenate-protected metal nanoparticles
(Georgetown University, 2011) -
Mechanistic Insights into Catalytic Bond Formation and Electrocatalytic Ammonia Oxidation
(Georgetown University, 2021)Computational chemistry is a useful technique to gain insight into reaction mechanisms when utilized in combination with synthesis and experimental characterization. Organometallic chemistry particularly benefits from a ... -
Mechanistic Insights into Copper Catalyzed sp3 C-H Functionalization
(Georgetown University, 2015)Direct C-H functionalization offers opportunities to modify carbon centers normally inert to traditional methods that rely on functional group manipulations, diversifying methods for complex organic molecule synthesis. ... -
Mechanistic Insights of Reactions Catalyzed by OmpB Lysine Methyltransferases
(Georgetown University, 2018)Protein lysine methylation of rickettsial OmpB (outer membrane protein B) has been implicated in the virulence of the typhus group of Rickettsia. N- and O-methylations have also been observed in virulence-relevant outer ... -
Mechanistic Studies of Copper and Iron Catalyzed Ammonia Oxidation
(Georgetown University, 2021)Global energy demand is increasing because of industrialization and population growth. Fossil fuels (oil, natural gas, and coal) provide about 88% of the energy needed to meet current demand. The two major problems associated ...
