Browsing Graduate Theses and Dissertations - Chemistry by Title
Now showing items 102-121 of 147
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Palladium-phosphinous acid-catalyzed carbon-carbon and carbon-heteroatom bond formation and synthesis of new antimalarial drugs
(Georgetown University, 2008) -
Pancake Bonding in Organic Radicals
(Georgetown University, 2017)Interactions between two closed-shell molecules are usually non-covalent such as van der Waals (vdW) interactions. A covalent-like multi-electron/multi-center (me/mc) intermolecular interaction, often termed as “pancake ... -
Phase Control of Diphenylureas Through Co-Crystallization and Template-Directed Methods
(Georgetown University, 2018)Phase selectivity of polymorphic diarylurea derivatives has been achieved through templated nucleation and co-crystallization techniques, and assorted methods for engineering the crystal growth of small, organic model ... -
Physiology Directed Drug Discovery in Multidrug Resistant Plasmodium falciparum
(Georgetown University, 2017)Resistance to front-line antimalarial therapies is a widespread issue, from early chloroquine failure to the more recent concerns of Artemisinin Combination Therapy (ACT) failure. Traditional methods of quantifying drug ... -
Preparation and Characterization of Chromium-Based Chalcospinel Materials
(Georgetown University, 2011)The goal of this thesis was to synthesize and characterize nanoparticles of the chalcogenide spinels CdCr2S4, CuCr2S4, and FeCr2S4 via a precursor method. In this thesis, I have synthesized dithiocarbamate precursors of ... -
Principles of Surface-Guided Protein Adsorption and Assembly Behavior on Nanopatterned Block Copolymers Revealed at The Single Protein Level
(Georgetown University, 2019)Protein adsorption on polymeric material surfaces is a ubiquitous process that plays a crucial role in many essential fields such as medical devices, biosensors, and food processing. Understanding and manipulating protein ... -
Probing the Physical and Chemical Properties of Zinc Oxide Nanorods Using Confocal Raman Spectroscopy
(Georgetown University, 2019)Zinc Oxide (ZnO) is a known waveguiding material whose bulk properties have widely been studied using Raman spectroscopy. Confining the material to the nanometer size domain affects the light-matter interaction of the ... -
REACTIVITY OF NITRIC OXIDE AND S-NITROSOTHIOLS WITH LOW-COORDINATE ZINC AND NICKEL CENTERS
(Georgetown University, 2009)Nitric oxide (NO) and biologically relevant sources of NO such as S-nitrosothiols (RSNOs) have become a topic of great interest due to their regulation of biological functions including vasorelaxation, neurotransmission, ... -
Reduction Potential Properties of Electron Transfer Proteins
(Georgetown University, 2018)Electron transfer reactions play an important role in biological processes such as photosynthesis, respiration, and nitrogen fixation. Here, the electron transfer properties of iron-sulfur (Fe-S) proteins and blue copper ... -
Ruthenium-Catalyzed Amine Alkylation with Alcohols Via the Borrowing Hydrogen Methodology: Scope, Mechanism, and Application
(Georgetown University, 2014)Amine alkylation reactions for the formation of C-N bonds are important in the fields of organic and biochemistry. Typical alkylation reactions require the use of stoichiometric amounts of toxic alkyl halide compounds or ... -
Self-assembly into Soft Materials of Molecules Derived from Naturally-occurring Fatty-acids
(Georgetown University, 2016)The self-assembly of molecular gelators has provided an attractive route for the construction of nanostructured materials with desired functionalities. A well-defined paradigm for the design of molecular gels is needed, ... -
Single-molecule Analysis of the Role of Flavin Adenine Dinulcleotide in the Conformational Landscapes of Drosophila Cryptochrome
(Georgetown University, 2020)The circadian clock regulates biological and behavioral adaptations in response to day-night cycles. Cryptochromes (CRYs) are members of a family of photolyases involved in DNA repair that are responsible for the oscillation ... -
Single-Source Precursors for the Synthesis of Layered Metal Chalcogenide Nanomaterials: LnX2, CuCrX2, and Bi2X3
(Georgetown University, 2021)Layered materials belong to a class of compounds in which individual, 2-dimensional units are stacked upon each other and held together by weak intermolecular forces. The layered nature of these materials render them ideal ... -
SMALL MOLECULE BINDING OF INTRINSICALY DISORDERED PROTEINS: MULTIPLE BINDERS ON MULTIPLE SITES
(Georgetown University, 2009)Intrinsically disordered (ID) proteins lack a stable tertiary structure and exist in an ensemble of rapidly inter-converting conformations. They are prevalent in human and other genomes, and are biologically active in ... -
Solid State Synthesis and Study of Porous Materials
(Georgetown University, 2019)The synthesis and study of porous materials is important due to their many potential uses (storage and separation of gases, catalysis, electronic devices, etc.) These materials are typically made by solvothermal methods, ... -
Spectroelectrochemical Investigation of the Electrocatalysis of Platinum-based Nanocatalysts for Fuel Cell Application
(Georgetown University, 2013)Spectroelectrochemical measurements, namely ATR-SEIRAS (attenuated total reflection-surface enhanced IR reflection absorption spectroscopy) and EC-NMR (electrochemical-nuclear magnetic resonance), were performed to determine ... -
STRUCTURAL AND CATALYTIC ROLES OF CYSTEINE RESIDUES IN HUMAN LYSYL-tRNA SYNTHETASE
(Georgetown University, 2014)Aminoacyl-tRNA synthetases (AARS) are essential and ubiquitous enzymes responsible for attaching amino acids to their cognate tRNAs during protein biosynthesis in a process known as aminoacylation. Comparing the amino ... -
Structural Changes and Diffusion of Vacancy Clusters in Diamond and Paracyclophane Cycloaddition: Insights into Unusual Carbon Bonding
(Georgetown University, 2013)High energy irradiation of diamond produces point defects that are observable by spectroscopy. While many defects have been confirmed such as the monovacancy V1, the divacancy V2, and various interstitials, most remain ... -
Structure-Property Relationships in Photoluminescent Lanthanide, Bismuth, and Lanthanide-Doped Bismuth Organic Hybrid Materials
(Georgetown University, 2021)Motivated by demands for novel luminescent materials and design strategies, this work focuses on the synthesis, structural characterization, and photoluminescent properties of solid-state lanthanide (Ln), bismuth (Bi), and ... -
Studies of Malarial Parasite Chloroquine Resistance Transporter and Kinase Proteins: Key Targets for Evolving Drug Therapies
(Georgetown University, 2017)The emergence of drug resistance is a developing problem in treating the global health burden that is Plasmodium (malaria) infections. Mutations in the Plasmodium falciparum chloroquine resistance transporter (PfCRT) have ...
