Browsing Graduate Theses and Dissertations - Chemistry by Title
Now showing items 134-147 of 147
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Targeting Plasmodium falciparum Phosphatidylinositol Kinases to Develop Next Generation Artemisinin Combination Therapies
(Georgetown University, 2019)Resistance to WHO mandated front-line antimalarial Artemisinin (ART) combination therapies (ACTs) is a pressing issue. Several synthetic endoperoxides have recently been proposed as superior to ART-based parent drugs ... -
Ternaries and alloys of magnetic semiconductors
(Georgetown University, 2017)Magnetic semiconductors are of great interest because of their coupled magnetic, electronic, and optical properties. Due to this coupling, magnetic semiconductors exhibit spin filtering effects, giant magnetoresistance, ... -
Th(IV) and U(IV)-Carboxylates: Species Formation, Stability, and Reactivity
(Georgetown University, 2020)This dissertation focuses on the synthesis and characterization of An(IV)-carboxylates, (An = Th and U), with the aim of gaining a more thorough understanding on how the identity of the organic ligand influences species ... -
TRANSFORMING TRIATOMIC MOLECULES INTO COMPLEX FUNCTIONAL MATERIALS
(Georgetown University, 2011)Perhaps because the dipole moment of CO2 is equal to zero, a widely held misperception is that this triatomic gas is kinetically and thermodynamically stable under most reaction conditions. As a result, only recently has ... -
TRANSITION METAL-CATALYZED CARBON-CARBON AND CARBON-NITROGEN BOND FORMATION AND ASYMMETRIC CATALYSIS WITH BISOXAZOLIDINE LIGANDS
(Georgetown University, 2012)Palladium-phosphinous acids and chlorophosphine analogues have attracted increasing interest due to their high catalytic activity in various organic transformations, long shelf-life and facile handling. In this thesis, it ... -
Tuning the activity of platinum electrocatalysts via size, shape and capping polymer
(Georgetown University, 2009) -
TWO APPROACHES TO THE STUDY OF PROTEIN INTERACTIONS WITH SMALL MOLECULES: (A) STRUCTURAL ANALYSIS OF PYRIDOXAL L-PHOSPHATE BINDING ENZYMES (B) PURIFICATION, RECONSTITUTION, AND DRUG-BINDING CAPABILITIES OF THE PLASMODIUM FALCIPARUM MULTIDRUG RESISTANCE PROTEIN (PfMDR1)
(Georgetown University, 2012)Structural genomics initiatives are producing new protein structures at a rate that will soon -
Understanding An(IV)-organic interactions via the solid-state structural chemistry of Th(IV) and U(IV)-carboxylates isolated from aqueous solution
(Georgetown University, 2016)Anthropogenic releases of actinides to the environment from activities such as actinide mining, weapons testing, nuclear accidents, and past inadequate disposal strategies underscore the need to develop a fundamental ... -
UNIQUE POLARIZED LIGHT-MATTER INTERACTION IN SINGLE ONE-DIMENSIONAL SEMICONDUCTING OXIDE NANOMATERIALS AND APPLICATIONS OF INDIUM TIN OXIDE NANOROD NETWORKS AS SURFACE ENHANCED RAMAN SPECTROSCOPY AND PHOTODETECTION PLATFORMS
(Georgetown University, 2016)With increasing demand of miniaturized optoelectronic, photonic, sensors and biodetection platforms, understanding and elucidating the fundamental material properties at nanoscale is crucial for development and advancement ... -
Unique Spatiotemporal Biomolecular Emission Profiles on Single Zinc Oxide Nanorods and Applications in Ultrasensitive Biosensing
(Georgetown University, 2016)There has been longstanding interest in improving the optical detection capabilities of fluorescence spectroscopy to achieve ultrahigh resolution and sensitivity in chemical and biological sensing applications. To promote ... -
UNIQUE SURFACE ADSORPTION BEHAVIORS OF SERUM PROTEINS ON CHEMICALLY UNIFORM AND ALTERNATING SURFACES
(Georgetown University, 2015)With increasing interests of studying proteins adsorption on the surfaces with nanoscale features in biomedical field, it is crucial to have fundamental understandings on how the proteins are adsorbed on such a surface and ... -
Unusual Carbon-Carbon Bonding in π-Conjugated Cyclic Hydrocarbons by High Pressure and in Quinonoid Diradicals by Mild Stimuli
(Georgetown University, 2018)This work presents a series of [n]-Cycloparaphenylenes ([n]CPPs, n=5, 6, 7, 8, 9, 10 and 12) subjected to ambient and high pressures and their in situ Raman spectra. All Raman experiments were done by our collaborates. ... -
Uric Acid Crystals
(Georgetown University, 2018)Uric acid is a crystalline component in kidney stones and gout deposits. In the work described herein, a variety of approaches are adopted to (1) create more soluble forms of uric acid, (2) examine the effects of additives ... -
Visualizing Enzymatic Activity Using Magnetic Resonance Molecular Imaging
(Georgetown University, 2013)Overexpression of ERK (MAP Kinase) and Pin1 is related to many types of cancer. Two pro-contrast agents, Gd-DOTA-APRTPGGRCKKK and Gd-DOTA-PRTPGGRCKK, which were hypothesized to be enzymatically activated to show greater ...
