Browsing Graduate Theses and Dissertations - Chemistry by Creation Date
Now showing items 41-60 of 167
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Bifunctional Hydrogenation Catalysis in Aqueous and Formic Acid/Triethylamine Media
(Georgetown University, 2012)Catalytic hydrogenation of organic compounds with molecular hydrogen is fast and efficient, but requires high gas pressures. Recently, there has been a revival in the field of catalytic transfer hydrogenation using formic ... -
Mechanisms of SNAP-25 Association with Botulinum Neurotoxin Light Chain A and SNARE Proteins
(Georgetown University, 2012)Botulism neurotoxins (BoNTs), a family of neurotoxins produced by the anaerobic bacterium Clostridium botulinum, are the most poisonous biological toxins known to man and are listed as category A bioterrorism agents by the ... -
Magnetic and thermal studies of doped rare-earth chalcogenide nanostructures in solution and the solid-state
(Georgetown University, 2012)The europium chalcogenides (oxide, sulfide, selenide) are intrinsically ferromagnetic semiconductors. Research with these types of materials is motivated by applications in fields such as spintronics, which can take advantage ... -
TWO APPROACHES TO THE STUDY OF PROTEIN INTERACTIONS WITH SMALL MOLECULES: (A) STRUCTURAL ANALYSIS OF PYRIDOXAL L-PHOSPHATE BINDING ENZYMES (B) PURIFICATION, RECONSTITUTION, AND DRUG-BINDING CAPABILITIES OF THE PLASMODIUM FALCIPARUM MULTIDRUG RESISTANCE PROTEIN (PfMDR1)
(Georgetown University, 2012)Structural genomics initiatives are producing new protein structures at a rate that will soon -
A New Path For C-H Bond Amination Using a Copper(I) β- Diketiminate Catalyst
(Georgetown University, 2012)The formation of C-N bonds is a core task in the construction of organic molecules for pharmaceuticals, natural products and materials. Traditionally, C-N bonds are formed through functional group manipulations such as ... -
Synthesis and Study of Magnetic Nanostructures
(Georgetown University, 2012)Nanostructures of magnetic semiconductors have widespread applications in the field of nanoscale device fabrication. Intrinsic magnetic semiconductors of the europium chalcogenide family (EuO, EuS, EuSe, EuTe) are of ... -
Adhesion Properties and Phase Transformations of Uric Acid Crystals
(Georgetown University, 2012)Uric acid, a product of protein metabolism, is the most abundant organic component in human kidney stones. At least six different crystalline phases of uric acid have been identified in kidney stones. Anhydrous uric acid ... -
ALKANE CHALCOGENOLATE - PROTECTED METAL NANOPARTICLES: SYNTHESIS, FORMATIONS, CHARACTERIZATIONS, AND INTERFACE INVESTIGATIONS
(Georgetown University, 2012)Organo selenolate - protected gold (Au) nanoparticles (NPs) have shown high potential for nanoelectronic applications, where electrochemical studies are crucial for understanding the charge transfer mechanism between the ... -
TRANSITION METAL-CATALYZED CARBON-CARBON AND CARBON-NITROGEN BOND FORMATION AND ASYMMETRIC CATALYSIS WITH BISOXAZOLIDINE LIGANDS
(Georgetown University, 2012)Palladium-phosphinous acids and chlorophosphine analogues have attracted increasing interest due to their high catalytic activity in various organic transformations, long shelf-life and facile handling. In this thesis, it ... -
Investigating Potential Mechanisms of Cytocidal Drug Resistance in Plasmodium falciparum
(Georgetown University, 2013)By quantifying antimalarial cytocidal activities (measured as LD50s) and comparing them to cytostatic activities (measured as IC50s), Paguio et al., 2011 showed a clear difference between some drug activities at different ... -
Exploring the Structure-Activity Relationship of Platinum and Platinum-based Electro-catalysts for the Methanol Electro-oxidation
(Georgetown University, 2013)This dissertation focuses on fundamental studies to improve the understanding of surface interactions on Pt electro-catalysts using the methanol oxidation reaction (MOR) as the model surface sensitive reaction. Advances ... -
Investigating the Cytostatic and Cytocidal Mechanisms of Quinoline Drug Resistance in Plasmodium falciparum
(Georgetown University, 2013)Efficacy of, mechanisms of action of, and resistance to chemotherapeutic agents targeted against the malarial parasite Plasmodium falciparum have historically been defined by quantifying cytostatic potency or growth-inhibition. ... -
METAL ION-MEDIATED INACTIVATION AND SMALL MOLECULE INHIBITION OF THE METALLOPROTEASE IN BOTULINUM NEUROTOXIN A
(Georgetown University, 2013)Botulinum neurotoxins are the causative agents of botulism and serotype A (BoNT/A) is the most persistent one among seven Clostridium botulinum serotypes. Current treatments for BoNT/A toxicity do not meet the demand of a ... -
Spectroelectrochemical Investigation of the Electrocatalysis of Platinum-based Nanocatalysts for Fuel Cell Application
(Georgetown University, 2013)Spectroelectrochemical measurements, namely ATR-SEIRAS (attenuated total reflection-surface enhanced IR reflection absorption spectroscopy) and EC-NMR (electrochemical-nuclear magnetic resonance), were performed to determine ... -
Synthesis of Organofluorine Compounds and Chirality Sensing with Tropos Ligands
(Georgetown University, 2013)Chiral organofluorine compounds play an important role in medicinal chemistry due to the beneficial effects of the fluorine moiety on the physiochemical and pharmacological profiles of drugs. The asymmetric synthesis of ... -
Visualizing Enzymatic Activity Using Magnetic Resonance Molecular Imaging
(Georgetown University, 2013)Overexpression of ERK (MAP Kinase) and Pin1 is related to many types of cancer. Two pro-contrast agents, Gd-DOTA-APRTPGGRCKKK and Gd-DOTA-PRTPGGRCKK, which were hypothesized to be enzymatically activated to show greater ... -
Nitric Oxide Reactivity at Biomimetic Copper and Zinc Complexes and Metal-free Frustrated Lewis Pairs
(Georgetown University, 2013)Since the discovery of nitric oxide (NO) in 1772, this simplest, stable free radical with one unpaired electron has been a target of ongoing research as an industrial intermediate, environmental pollutant, and more recently, ... -
Gels from Borate-Crosslinked Partially Hydrolyzed Poly(vinyl acetate)s: Characterization of Physical and Chemical Properties and Applications in Art Conservation
(Georgetown University, 2013)The formation of gel-like dispersions from borate-crosslinked, partially hydrolyzed poly(vinyl acetate)s (xPVAc, where x is the percent of hydrolysis) and their application for treatment of art is explored. It is shown ... -
Structural Changes and Diffusion of Vacancy Clusters in Diamond and Paracyclophane Cycloaddition: Insights into Unusual Carbon Bonding
(Georgetown University, 2013)High energy irradiation of diamond produces point defects that are observable by spectroscopy. While many defects have been confirmed such as the monovacancy V1, the divacancy V2, and various interstitials, most remain ... -
STRUCTURAL AND CATALYTIC ROLES OF CYSTEINE RESIDUES IN HUMAN LYSYL-tRNA SYNTHETASE
(Georgetown University, 2014)Aminoacyl-tRNA synthetases (AARS) are essential and ubiquitous enzymes responsible for attaching amino acids to their cognate tRNAs during protein biosynthesis in a process known as aminoacylation. Comparing the amino ...
