Browsing Graduate Theses and Dissertations - Pharmacology by Creation Date
Now showing items 1-20 of 43
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Comparison of the catalytic activities of members of the preproricin gene family of Ricinus communis
(Georgetown University, 2008) -
SPECIFICITY OF INHIBITORY CONTROL OF CORTICAL INTERNEURONS IN LAYER 4 OF MOUSE SOMATOSENSORY BARREL CORTEX
(Georgetown University, 2009)Cortical processing of sensory information relies on a diversity of inhibitory control. This thesis examines the cell type specificity in layer 4 of mouse somatosensory barrel cortex of two understudied mechanisms of GABA ... -
Novel regulatory mechanisms of cardiac L-type calcium channel
(Georgetown University, 2010) -
Regulation of striatal medium spiny neuron GABAA receptor mediated tonic current
(Georgetown University, 2010) -
Role of BDNF-TRKB signaling in development and maintenance of the basal ganglia
(Georgetown University, 2010) -
Novel Roles for TRPA1 and TRPV1 in nutrient sensing and obesity
(Georgetown University, 2011)In the first part of this thesis I explored a role for the capsaicin receptor TRPV1 in the regulation of feeding and body mass. On a diet containing 4.5% fat, wild-type and TRPV1-null mice gained equivalent body mass. On ... -
ROLE OF DENDRITIC BDNF SYNTHESIS IN ADULT NEUROGENESIS AND SPINE MORPHOGENESIS
(Georgetown University, 2011)Substantial evidence has demonstrated that dendritic protein synthesis is an important source of new protein during the expression of synaptic plasticity. Dendritically synthesized brain-derived neurotrophic factor (BDNF) ... -
The role of the intermediate and deep layers of the superior colliculus in the control of posture and movement in the nonhuman primate
(Georgetown University, 2011)The intermediate and deep layers of the superior colliculus (DLSC) represent a principle target of basal ganglia output via the nigrotectal pathway from the substantia nigra pars reticulata (SNpr). In the nonhuman primate, ... -
Studies of Brainstem Control of Vagal Outflow to the Stomach
(Georgetown University, 2012)The vagus nerve is a vital component of the brain-gut axis by which the activity of the gastrointestinal tract, particularly the stomach is modulated by the CNS. Through two distinct sphincters, the lower esophageal ... -
Cellular, Structural and Functional Characterization of Hyperoxia-induced White Matter Injury in the Developing Brain
(Georgetown University, 2012)Diffuse white matter injury (DWMI) is frequently associated with impaired neurological development in pre-mature infants. To characterize the cellular, structural and functional basis of hyperoxia-induced DWMI, the cellular ... -
Regulation of Neuronal Nicotinic Receptor Expression by Novel Ligands and Mechanisms
(Georgetown University, 2012)Chronic nicotine administration increases the density of α4β2 neuronal nicotinic acetylcholine receptors (nAChRs) in brain. Nicotine up-regulates these receptors in numerous research models, including cultured ... -
ACTIVITY-INDUCIBLE KINASE PLK2 REGULATES APP AMYLOIDOGENIC PROCESSING AND Aβ MEDIATED SYNAPTIC DEPRESSION
(Georgetown University, 2012)Alzheimer's disease (AD) is a progressive neurodegenerative disorder with cognitive deficits. Amyloidogenic processing of amyloid precursor protein (APP) produces Aβ peptides, the major component of hallmark AD senile ... -
TOXIC SIGNALING OF METABOTROPIC GLUTAMATE 1 RECEPTOR IN CEREBELLAR NEURONS: INVOLVEMENT IN ABERRANT CELL CYCLE RE-ENTRY
(Georgetown University, 2012)Previously, we have shown that mGlu1 receptors play a dual role in neuronal apoptosis: mGlu1 receptor overexpression led to massive cell death while several mGlu1 receptor agonists protected neurons from this receptor-induced ... -
Calcium Signaling in Cardiac Myocytes: Contributions from Mitochondria, Sodium-Calcium Exchanger, and Ryanodine Receptor
(Georgetown University, 2013)This dissertation explores three critical players in the cardiac Ca2+ signaling pathway. First, I examined the role of mitochondria in Ca2+ signaling by generating a Ca2+ probe, mitycamE31Q, with 1.5μM affinity for ... -
ELUCIDATING THE ROLE OF INSULIN-LIKE GROWTH FACTOR 2 MRNA BINDING PROTEIN 2 IN THE PATHOGENESIS OF TYPE 2 DIABETES
(Georgetown University, 2013)The prevalence of type 2 diabetes mellitus (T2D) has reached epidemic proportions, making it a major public health concern. T2D is known to be highly heritable, but until recently its genetic architecture was largely ... -
New Molecular Properties of Metabotropic Glutamate Receptors
(Georgetown University, 2013)This thesis is divided into three distinct sections. The work in Chapter I was designed to describe two newly identified exons found in the GRM1 gene that encode a novel splice variant of metabotropic glutamate (mGlu) 1 ... -
TRANSCRIPTIONAL REPRESSION OF THE NUCLEAR RECEPTOR COACTIVATOR AIB1 BY FOXG1 LEADS TO APOPTOSIS IN BREAST CANCER CELLS
(Georgetown University, 2013)The oncogene nuclear receptor coactivator amplified in breast cancer 1 (AIB1) is a transcriptional coactivator that is overexpressed in various types of human cancers. However, the molecular mechanisms controlling AIB1 ...
