Browsing Graduate Theses and Dissertations - Pharmacology by Title
Now showing items 1-20 of 43
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ACTIVITY-DEPENDENT REGULATION OF AMYLOID PRECURSOR PROTEIN (APP) BY POLO-LIKE KINASE 2 (PLK2): NOVEL ROLES IN SYNAPTIC PLASTICITY
(Georgetown University, 2016)The brain uses a special feature, synaptic plasticity, for learning and memory. As forms of synaptic plasticity, associative plasticity, long-term potentiation (LTP) and long-term depression (LTD), is a positive feedback ... -
ACTIVITY-INDUCIBLE KINASE PLK2 REGULATES APP AMYLOIDOGENIC PROCESSING AND Aβ MEDIATED SYNAPTIC DEPRESSION
(Georgetown University, 2012)Alzheimer's disease (AD) is a progressive neurodegenerative disorder with cognitive deficits. Amyloidogenic processing of amyloid precursor protein (APP) produces Aβ peptides, the major component of hallmark AD senile ... -
Associations of Nicotinic Acetylcholine Receptor Subunits Expressed in the Rat Habenula
(Georgetown University, 2016)The goals of this study were to define the nicotinic acetylcholine receptor (nAChR) subtypes expressed in the rat habenula. This was done using three main techniques: single and sequential immunoprecipitation using ... -
Calcium Signaling in Cardiac Myocytes: Contributions from Mitochondria, Sodium-Calcium Exchanger, and Ryanodine Receptor
(Georgetown University, 2013)This dissertation explores three critical players in the cardiac Ca2+ signaling pathway. First, I examined the role of mitochondria in Ca2+ signaling by generating a Ca2+ probe, mitycamE31Q, with 1.5μM affinity for ... -
Cellular, Structural and Functional Characterization of Hyperoxia-induced White Matter Injury in the Developing Brain
(Georgetown University, 2012)Diffuse white matter injury (DWMI) is frequently associated with impaired neurological development in pre-mature infants. To characterize the cellular, structural and functional basis of hyperoxia-induced DWMI, the cellular ... -
Cholinergic Modulation of GABAergic Inhibition Dynamics In The Striatum
(Georgetown University, 2014)The striatum contains medium spiny neurons (MSNs) classified by their axonal projection and expression of dopamine receptors into D1+ and D2+ MSNs; and interneurons including choline acetyltransferase expressing interneurons ... -
Chronic morphine vs. morphine withdrawal: differential effects on HIV neurotoxicity through the expression of CCL5
(Georgetown University, 2014)The effect of opioids in the progression of Human Immunodeficiency Virus (HIV)-associated Neurocognitive Disorders (HAND) remains under debate. M-tropic, CCR5-receptor preferring strains of HIV are associated with primary ... -
Comparison of the catalytic activities of members of the preproricin gene family of Ricinus communis
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Direct and Indirect Inhibition of the Mediodorsal Thalamus Affects Seizure Propagation and Cognition
(Georgetown University, 2019)Temporal lobe epilepsy (TLE) is one of the most common neurological disorders, and is characterized by spontaneous, recurrent seizures. Seizures in TLE do not propagate randomly, but instead follow anatomically constrained ... -
Efficacy and Safety Profile of Cannabinoid-targeted Compounds for Seizure Control in Immature Animals
(Georgetown University, 2018)Epilepsy is the fourth most prevalent neurological disorder worldwide, and is characterized by spontaneous, recurrent seizures. However, in neonates and children, seizures are the single most common neurological event to ... -
ELUCIDATING THE ROLE OF INSULIN-LIKE GROWTH FACTOR 2 MRNA BINDING PROTEIN 2 IN THE PATHOGENESIS OF TYPE 2 DIABETES
(Georgetown University, 2013)The prevalence of type 2 diabetes mellitus (T2D) has reached epidemic proportions, making it a major public health concern. T2D is known to be highly heritable, but until recently its genetic architecture was largely ... -
Fibroblast Growth Factor Binding Protein 3: A Novel Target for Glucose Intolerance and Nonalcoholic Fatty Liver Disease Treatment
(Georgetown University, 2018)ABSTRACT -
FUNCTION AND SIGNAL TRANSDUCTION OF METABOTROPIC GLUTAMATE RECEPTOR 1 IN CEREBELLAR GRANULE CELLS
(Georgetown University, 2014)Glutamate is the predominant excitatory neurotransmitter in the mammalian brain, activating ionotropic and metabotropic glutamate (mGlu1) receptors. mGlu1 receptors are highly expressed in cerebellar granule cells, but ... -
Mechanisms of HIV-1 gp120 Neurotoxicity: The Role of Microtubules
(Georgetown University, 2019)Despite the introduction of antiretroviral therapy in 1996, about 50% of HIV-positive individuals demonstrate cognitive impairments known as HIV-associated neurocognitive disorders (HAND). Although neurons cannot be infected ... -
MMP-1 Overexpression Selectively Alters Inhibition in D1 Spiny Projection Neurons in the Nucleus Accumbens and Disrupts Amphetamine Induced Locomotion
(Georgetown University, 2018)Protease activated receptor-1 (PAR-1) and its ligand, matrix metalloproteinase-1 (MMP-1), are altered in several neurodegenerative diseases. PAR-1 and MMP-1 signaling impact neuronal excitation and inhibition in various ... -
New Molecular Properties of Metabotropic Glutamate Receptors
(Georgetown University, 2013)This thesis is divided into three distinct sections. The work in Chapter I was designed to describe two newly identified exons found in the GRM1 gene that encode a novel splice variant of metabotropic glutamate (mGlu) 1 ... -
Nonnavigational Spatial Memory Processing in the Medial Temporal Lobe and Goal-directed Behavior in Rhesus Macaques
(Georgetown University, 2020)The hippocampus and cortical areas of the medial temporal lobe have a critical role in navigational spatial memory, as has been well-established in rodent models. However, nonnavigational spatial memory is more difficult ...
