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ELUCIDATING THE ROLE OF INSULIN-LIKE GROWTH FACTOR 2 MRNA BINDING PROTEIN 2 IN THE PATHOGENESIS OF TYPE 2 DIABETES
(Georgetown University, 2013)
The prevalence of type 2 diabetes mellitus (T2D) has reached epidemic proportions, making it a major public health concern. T2D is known to be highly heritable, but until recently its genetic architecture was largely ...
ACTIVITY-DEPENDENT REGULATION OF AMYLOID PRECURSOR PROTEIN (APP) BY POLO-LIKE KINASE 2 (PLK2): NOVEL ROLES IN SYNAPTIC PLASTICITY
(Georgetown University, 2016)
The brain uses a special feature, synaptic plasticity, for learning and memory. As forms of synaptic plasticity, associative plasticity, long-term potentiation (LTP) and long-term depression (LTD), is a positive feedback ...
ROLE OF DENDRITIC BDNF SYNTHESIS IN ADULT NEUROGENESIS AND SPINE MORPHOGENESIS
(Georgetown University, 2011)
Substantial evidence has demonstrated that dendritic protein synthesis is an important source of new protein during the expression of synaptic plasticity. Dendritically synthesized brain-derived neurotrophic factor (BDNF) ...
The role of cancer chemotherapeutic agents in the treatment of pulmonary arterial hypertension
(Georgetown University, 2015)
The Role of Metabotropic Glutamate Receptor 1 (MGLU1) Dependent Signaling in Glioma Cell Line Viability
(Georgetown University, 2017)
Glioma refers to malignant central nervous system tumors that have histological characteristics in common with glial cells. The most prevalent type, glioblastoma multiforme, is associated with a poor prognosis and few ...