Browsing Graduate Theses and Dissertations - Neuroscience by Creator "Caccavano, Adam Peter"

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Hippocampal Microcircuit Alterations in Early Amyloid Pathology: A Selective Impairment of Parvalbumin-Expressing Basket Cells During Sharp Wave Ripple Events

Caccavano, Adam Peter (Georgetown University, 2020)

Memory disruption in mild cognitive impairment (MCI) and Alzheimer’s disease (AD) is poorly understood, particularly at early stages preceding neurodegeneration. In mouse models of AD, there are disruptions to sharp wave ...