Browsing Graduate Theses and Dissertations - Neuroscience by Creator "Huang, Jeffrey K"
Now showing items 1-5 of 5
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Creatine Synthesis and Supplementation Regulates Central Nervous System Postnatal Development and Injury
(Georgetown University, 2021)Cerebral creatine deficiency syndrome (CCDS) is an inborn error of metabolism characterized by intellectual delays, seizures, and autistic-like behavior. Exactly how endogenously synthesized creatine regulates central ... -
Immunomodulatory Effects of Interleukin-4 Induced Protein 1 (IL4I1) on Multiple Sclerosis Patient Derived Lymphocytes
(Georgetown University, 2018)Multiple sclerosis (MS) is a chronic inflammatory neurodegenerative disease of the central nervous system (CNS) that afflicts over 2.3 million individuals worldwide. The pathogenesis of MS involves autoimmune destruction ... -
Retinoic Acid Is Required for Oligodendrocyte Precursor Cell Production and Differentiation in the Postnatal Mouse Corpus Callosum
(Georgetown University, 2019)Myelination of the central nervous system (CNS) relies on the production of oligodendrocytes (OLs) from oligodendrocyte precursor cells (OPCs). During the first month of postnatal life, OPCs that eventually populate the ... -
THE ROLE OF CREATINE IN PROMOTING OLIGODENDROCYTE SURVIVAL AND MODULATING AXONAL MITOCHONDRIA IN THE CNS
(Georgetown University, 2017)Oligodendrocytes maintain neuronal integrity in the central nervous system (CNS). Chronic oligodendrocyte loss, a feature of the demyelinating disorder multiple sclerosis (MS), contributes to axonal dysfunction. Current ... -
Spatiotemporal Evolution of Inflammatory Demyelinating Lesions in Cerebral White Matter
(Georgetown University, 2019)Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS) affecting millions of patients worldwide. Despite its prevalence, the disease is imperfectly characterized and does not ...
