Browsing Graduate Theses and Dissertations - Neuroscience by Creator "Rebeck, G. William"
Now showing items 1-7 of 7
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Alpha-synuclein and its direct effects on microglial activation
(Georgetown University, 2013)Accumulation, deposition and dysfunction of α-synuclein occur in a class of neurodegenerative disorders known as synucleinopathies. These include Parkinson's disease, dementia with Lewy bodies, and multiple system ... -
Cholesterol 24S-hydroxylase: Involvement in Brain Injury and Disease.
(Georgetown University, 2008)Here we investigated whether traumatic brain injury (TBI) altered the regulation of cholesterol 24S-hydroxylase (Cyp46), an enzyme that converts cholesterol to the more hydrophilic 24S-hydroxycholesterol. We examined changes ... -
EFFECTS OF ALZHEIMER’S DISEASE GENETIC RISK FACTOR APOE4 ON THE NORMAL BRAIN
(Georgetown University, 2016)Over 70 million Americans inherit the strongest genetic risk factor for Alzheimer’s disease (AD), the E4 allele for apolipoprotein E (APOE4), but have few strategies to reduce their risk. To identify markers associated ... -
Human APOE4 Affects Microglial Reactivity and Spatial Cognition in a Mouse Model of Alzheimer's Disease Risk
(Georgetown University, 2015)Alzheimer's disease (AD) is a progressive age-related neurodegenerative disorder that results in declarative memory deficits. Apolipoprotein e4 (APOE-ε4) is the strongest genetic risk factor for developing AD, and influences ... -
A Novel Role for Fyn in ApoER2 Regulation
(Georgetown University, 2014)Apolipoprotein E Receptor 2 (ApoER2) and the tyrosine kinase Fyn are both members of the Reelin pathway, a signaling pathway essential for the laminar formation of the cortex, hippocampus, and cerebellum during development ... -
The Effects of Diet Induced Obesity on Central Nervous System Function of APOE Mice
(Georgetown University, 2021)APOE4 is the strongest genetic risk factor for Alzheimer’s Disease (AD) and obesity is one of the most common environmental risk factors for AD. With 25% of the population being APOE4 carriers and 40% of the population ... -
Using APOE Genotype to Identify New Biomarkers of Alzheimer's Disease Risk
(Georgetown University, 2013)Alzheimer's disease (AD), unlike the other leading causes of death, does not have a cure or an effective intervention strategy. The largest genetic risk factor for AD is APOE, with the ε4 allele increasing and the ε2 allele ...
