Browsing Graduate Theses and Dissertations - Neuroscience by Creator "Vicini, Stefano"
Now showing items 1-9 of 9
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A-ephrins in Neuropsychiatric Spectrum Disorder Models
(Georgetown University, 2014)Neuropsychiatric spectrum disorders such as autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD) are frequently comorbid and exhibit overlapping abnormalities in both behavioral symptoms and ... -
Acute Microglial Responses to Single Non-Epileptogenic vs. Epileptogenic Seizures in Mouse Hippocampus
(Georgetown University, 2019)As the resident macrophage of the central nervous system, microglia are in a uniquely privileged position to both affect and be affected by neuroinflammation, neuronal activity and injury, which are all hallmarks of seizures ... -
Changes in Hippocampal Synaptic Plasticity Following Exposure to High Frequency Head Impacts (HF-HI)
(Georgetown University, 2020)Concussions account for over 80% of all cases of TBI reported each year. Sustaining multiple concussions is associated with the development of lasting cognitive and memory impairments. Chronic traumatic encephalopathy ... -
The Effects of Inflammation on Dorsal Striatal Spiny Projection Neurons
(Georgetown University, 2017)Neuroinflammation precedes neuronal loss in striatal neurodegenerative diseases and can be exacerbated by the release of proinflammatory molecules by microglia. These molecules can affect trafficking of glutamate receptors. ... -
From Neurons to Behavior: A Path Towards Brain Stimulation as a Treatment for Repetitive Head Impacts
(Georgetown University, 2023)Traumatic brain injury is the most common neurological disorder and 80% consist of mild traumatic brain injury. The severity and persistence of cognitive symptoms is increased with additional repeat injuries. A high frequency ... -
Hippocampal Microcircuit Alterations in Early Amyloid Pathology: A Selective Impairment of Parvalbumin-Expressing Basket Cells During Sharp Wave Ripple Events
(Georgetown University, 2020)Memory disruption in mild cognitive impairment (MCI) and Alzheimer’s disease (AD) is poorly understood, particularly at early stages preceding neurodegeneration. In mouse models of AD, there are disruptions to sharp wave ... -
Mechanisms Behind the GABA-Mediated Field Potential in Hippocampus in the in vitro 4-aminopyridine Model of Epilepsy
(Georgetown University, 2012)Local field potentials (LFPs) mediated by GABAergic transmission have been recorded from resected human epileptic brain tissue, as confirmed by blockade of these events upon exposure to GABAergic transmission antagonists, ... -
Synapse- and cell-specific plasticity in the mature hippocampus
(Georgetown University, 2014)The central nervous system (CNS) is a living, breathing electrical circuit which learns and remembers by altering its own connectivity. Neurons, the electrical cells of the CNS, are thought to encode information by adjusting ... -
Synaptic Homeostasis: Insights from Drosophila Autsim Models
(Georgetown University, 2023)Autism Spectrum Disorders (ASD), epilepsy, and Intellectual and Developmental Disability (IDD) are highly prevalent and pervasive neurodevelopmental disorders. However, there are no FDA-approved drugs for the treatment of ...
