Browsing Graduate Theses and Dissertations - Neuroscience by Creation Date
Now showing items 1-20 of 68
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Morphine activation of stress pathways alters peripheral immune cell signaling
(Georgetown University, 2008)Morphine is routinely used as an analgesic for acute and chronic pain often in people at greater risk for infection, in spite of the fact that morphine suppresses immune function. Recent studies indicate that morphine ... -
Cholesterol 24S-hydroxylase: Involvement in Brain Injury and Disease.
(Georgetown University, 2008)Here we investigated whether traumatic brain injury (TBI) altered the regulation of cholesterol 24S-hydroxylase (Cyp46), an enzyme that converts cholesterol to the more hydrophilic 24S-hydroxycholesterol. We examined changes ... -
Microglial LRP1 modulates JNK activation : a signaling cascade that also regulates apolipoprotein E levels
(Georgetown University, 2009) -
Homeostatic control of AMPA receptor strength and subunit composition by Polo-like kinase 2
(Georgetown University, 2009) -
Investigating the neural code for single-word reading
(Georgetown University, 2009) -
Endogenous acidification of the inhibitory synapse : proton amplification of GABAA-mediated neurotransmission
(Georgetown University, 2009) -
Genetic regulation of the generation of neuronal diversity in the developing mammalian basal forebrain
(Georgetown University, 2010) -
The role of N-acetylaspartylglutamate (NAAG) in the amygdala
(Georgetown University, 2010) -
Roles for EphA4-mediated intercellular signaling in corticogenesis and in the development of the peripheral somatosensory system
(Georgetown University, 2010) -
The role of Fyn in the pathogenic processes of Alzheimer's disease
(Georgetown University, 2010) -
Magnetic resonance imaging (MRI) studies of the human auditory brain : objects, sequences, and dysfunction
(Georgetown University, 2010) -
Generalization and maintenance in aphasia rehabilitation
(Georgetown University, 2010) -
NEURAL COMPUTATIONS UNDERLYING SPEECH RECOGNITION IN THE HUMAN AUDITORY SYSTEM
(Georgetown University, 2011)Current theories of speech perception in the human brain propose two separate, hierarchically organized cortical processing streams, a ventral and a dorsal stream. The ventral stream is generally believed to mediate acoustic ... -
Sequelae of Neonatal Antiepileptic Drug Exposure in Rats
(Georgetown University, 2011)Antiepileptic drugs (AEDs) are first-line seizure treatments. Despite use in pregnancy and early life, their impact on brain maturation is unclear. This can only be assessed in preclinical models (e.g., rats), as seizures ... -
Neuroprotective signaling through metabotropic glutamate receptor 1
(Georgetown University, 2011) -
THE EFFECTS OF ROBOTIC TRAINING AND CORTICAL STIMULATION ON REACHING SKILL AFTER CHRONIC STROKE
(Georgetown University, 2011)<bold>BACKGROUND: </bold> Reaching in three dimensional (3D) space, crucial for activities of daily living (ADLs), is deficient after stroke. The effects of cortical stimulation on 3D robotic training for patients with ... -
Inhibitory neurotransmission in the Fmr1 knockout mouse model of Fragile X Syndrome : region- and circuit-specific deficits
(Georgetown University, 2011) -
SLOW GABAERGIC TRANSMISSION DEFICITS IN THE BASOLATERAL AMYGDALA IN A MOUSE MODEL OF FRAGILE-X SYNDROME
(Georgetown University, 2012)Fragile-X Syndrome (FXS), caused by transcriptional silencing of the fmr1 gene, is the leading cause of inherited intellectual disability. Comorbidities of FXS such as autism are typically linked to excitatory/inhibitory ... -
ALPHA-SYNUCLEIN AND THE MULTIPLE HIT HYPOTHESIS OF PARKINSON'S DISEASE
(Georgetown University, 2012)Alpha-synuclein has been linked to the pathogenesis of Parkinson's disease and other synucleinopathies through its propensity to form toxic oligomers. The exact mechanism for oligomeric synuclein-directed cell vulnerability ... -
THE NEURAL SUBSTRATES UNDERLYING BOTH SPELLING AND READING
(Georgetown University, 2012)Written language forms a cornerstone of human communication and understanding. In order to understand why written language can be used skillfully by some and not by others, it is important to investigate the neural basis ...
